Mouse Visual Cortex Is Modulated by Distance Traveled and by Theta Oscillations
| Autor: | Julien Fournier, Aman B. Saleem, Miles J. Wells, E. Mika Diamanti, Matteo Carandini, Kenneth D. Harris |
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| Přispěvatelé: | University College of London [London] (UCL), Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neurosciences Paris Seine (NPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des systèmes perceptifs (LSP), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institute of Ophthalmology [London], Institute of Neurology [London], Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), CeZaMe - Cervelet, navigation et mémoire = Memory, Navigation and Aging (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Gestionnaire, Hal Sorbonne Université |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Sensory processing hippocampus medicine.medical_treatment [SDV]Life Sciences [q-bio] Phase (waves) theta oscillation Action Potentials Spatial Behavior Hippocampus Hippocampal formation Biology General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Reward Report Oscillation (cell signaling) medicine Animals Theta Rhythm navigation CA1 Region Hippocampal primary visual cortex Visual Cortex Neurons Pyramidal Cells Theta oscillations Mice Inbred C57BL [SDV] Life Sciences [q-bio] 030104 developmental biology Visual cortex medicine.anatomical_structure distance coding virtual reality Female General Agricultural and Biological Sciences Licking Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Biology-CB Current Biology-CB, Elsevier, 2020, 30 (19), pp.3811-3817.e6. ⟨10.1016/j.cub.2020.07.006⟩ Current Biology-CB, 2020, 30 (19), pp.3811-3817.e6. ⟨10.1016/j.cub.2020.07.006⟩ Current Biology |
| ISSN: | 0960-9822 1879-0445 |
| DOI: | 10.1016/j.cub.2020.07.006⟩ |
| Popis: | Summary The visual responses of neurons in the primary visual cortex (V1) are influenced by the animal’s position in the environment [1, 2, 3, 4, 5]. V1 responses encode positions that co-fluctuate with those encoded by place cells in hippocampal area CA1 [2, 5]. This correlation might reflect a common influence of non-visual spatial signals on both areas. Place cells in CA1, indeed, do not rely only on vision; their place preference depends on the physical distance traveled [6, 7, 8, 9, 10, 11] and on the phase of the 6–9 Hz theta oscillation [12, 13]. Are V1 responses similarly influenced by these non-visual factors? We recorded V1 and CA1 neurons simultaneously while mice performed a spatial task in a virtual corridor by running on a wheel and licking at a reward location. By changing the gain that couples the wheel movement to the virtual environment, we found that ∼20% of V1 neurons were influenced by the physical distance traveled, as were ∼40% of CA1 place cells. Moreover, the firing rate of ∼24% of V1 neurons was modulated by the phase of theta oscillations recorded in CA1 and the response profiles of ∼7% of V1 neurons shifted spatially across the theta cycle, analogous to the phase precession observed in ∼37% of CA1 place cells. The influence of theta oscillations on V1 responses was more prominent in putative layer 6. These results reveal that, in a familiar environment, sensory processing in V1 is modulated by the key non-visual signals that influence spatial coding in the hippocampus. Graphical Abstract Highlights • We compared responses of mouse V1 and CA1 during navigation in virtual reality • Similar to CA1 neurons, V1 neurons are influenced by physical distance traveled • V1 responses are modulated by theta oscillations recorded in hippocampus • Positions encoded by V1 shift spatially with the phase of the theta oscillation Fournier et al. compare responses of hippocampus and visual cortex in mice navigating a virtual reality. They find that, similar to hippocampus, activity in visual cortex is influenced by the physical distance traveled in an environment. In addition, theta oscillations modulate the activity of visual cortical neurons and their position coding. |
| Databáze: | OpenAIRE |
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