Targeted proteomic analysis of habitual coffee consumption
| Autor: | Lars Lind, Sölve Elmståhl, Stefan Söderberg, Johan Ärnlöv, Stefan Gustafsson, Marilyn C. Cornelis, Karl Michaëlsson, Erik Ingelsson, Johan Sundström |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Leptin
Male Proteomics 0301 basic medicine Fas Ligand Protein Population 030209 endocrinology & metabolism Coffee consumption TNF-Related Apoptosis-Inducing Ligand Coffee 03 medical and health sciences 0302 clinical medicine Risk Factors Surveys and Questionnaires Environmental health Internal Medicine Humans Medicine Chitinase-3-Like Protein 1 Longitudinal Studies Prospective Studies education Aged education.field_of_study 030109 nutrition & dietetics business.industry Middle Aged 3. Good health Biotechnology Cardiovascular Diseases Female business Biomarkers |
| Zdroj: | Journal of Internal Medicine. 283:200-211 |
| ISSN: | 0954-6820 |
| Popis: | Coffee drinking has been implicated in mortality and a variety of diseases but potential mechanisms underlying these associations are unclear. Large-scale systems epidemiological approaches may offer novel insights to mechanisms underlying associations of coffee with health.We performed an analysis of known and novel protein markers linked to cardiovascular disease and their association with habitual coffee intake in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, n = 816) and followed up top proteins in the Uppsala Longitudinal Study of Adult Men (ULSAM, n = 635) and EpiHealth (n = 2418).In PIVUS and ULSAM, coffee intake was measured by 7-day dietary records whilst a computer-based food frequency questionnaire was used in EpiHealth. Levels of up to 80 proteins were assessed in plasma by a proximity extension assay.Four protein-coffee associations adjusted for age, sex, smoking and BMI, met statistical significance in PIVUS (FDR5%, P2.31 × 10The current study supports an inverse association between coffee intake and plasma LEP and CHI3L1 levels. The coffee-CHI3L1 association is novel and warrants further investigation given links between CHI3L1 and health conditions that are also potentially influenced by coffee. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text