malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication

Autor: Kaslow, DC, Okumu, F, Wells, TNC, Rabinovich, R, Bassat, Q, Birkett, A, Bompart, F, Burt, A, Chaccour, C, Chitnis, C, Culpepper, J, Domingo, G, Duffy, P, Ghani, A, Greenwood, B, Hall, BF, Hamon, N, Jacobs-Lorena, M, James, S, Koram, KA, Kremsner, P, Kumar, A, Leroy, D, Leroy, O, Lindsay, S, Majambere, S, Mbogo, C, McCarthy, J, Qi, G, Rasgon, J, Richardson, J, Richie, T, Sauerwein, R, Slutsker, L, Vekemans, J
Přispěvatelé: Bill & Melinda Gates Foundation, Medical Research Council (MRC)
Rok vydání: 2017
Předmět:
0301 basic medicine
Plasmodium
GENE DRIVE SYSTEM
Biomedical Research
Mosquito Control
Computer science
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
law.invention
DOUBLE-BLIND
0302 clinical medicine
law
Medicine and Health Sciences
HIGH-THROUGHPUT ASSAY
Protozoans
Vaccines
Collection Review
Vector control
Malarial Parasites
Eukaryota
Drugs
General Medicine
11 Medical And Health Sciences
TRANSMISSION-BLOCKING ACTIVITY
Parasitic diseases
3. Good health
Infectious Diseases
Transmission (mechanics)
Malalties parasitàries
Risk analysis (engineering)
Medicine
Malaria control
Life Sciences & Biomedicine
Drug Research and Development
Infectious Disease Control
RESISTANT ANOPHELES-GAMBIAE
030231 tropical medicine
Severe disease
Malària
Antimalarials
03 medical and health sciences
Medicine
General & Internal
All institutes and research themes of the Radboud University Medical Center
Malaria elimination
General & Internal Medicine
Malaria Vaccines
Parasite Groups
Parasitic Diseases
medicine
Animals
Humans
Disease Eradication
VIVAX INFECTION
Pharmacology
Science & Technology
NUCLEIC-ACID AMPLIFICATION
Organisms
Biology and Life Sciences
PLASMODIUM-FALCIPARUM MALARIA
PYRIPROXYFEN MIXTURE NET
Tropical Diseases
medicine.disease
Parasitic Protozoans
Insect Vectors
Malaria
030104 developmental biology
Direct Treatment
Insecticide resistance
BLOOD-STAGE MALARIA
Parasitology
Apicomplexa
Zdroj: Plos Medicine, 14, e1002455-e1002455
Plos Medicine, 14, 11, pp. e1002455-e1002455
PLoS Medicine, Vol 14, Iss 11, p e1002455 (2017)
PLoS medicine, 2017, Vol.14(11), pp.e1002455 [Peer Reviewed Journal]
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS Medicine
ISSN: 1549-1277
Popis: Since the turn of the century, a remarkable expansion has been achieved in the range and effectiveness of products and strategies available to prevent, treat, and control malaria, including advances in diagnostics, drugs, vaccines, and vector control. These advances have once again put malaria elimination on the agenda. However, it is clear that even with the means available today, malaria control and elimination pose a formidable challenge in many settings. Thus, currently available resources must be used more effectively, and new products and approaches likely to achieve these goals must be developed. This paper considers tools (both those available and others that may be required) to achieve and maintain malaria elimination. New diagnostics are needed to direct treatment and detect transmission potential; new drugs and vaccines to overcome existing resistance and protect against clinical and severe disease, as well as block transmission and prevent relapses; and new vector control measures to overcome insecticide resistance and more powerfully interrupt transmission. It is also essential that strategies for combining new and existing approaches are developed for different settings to maximise their longevity and effectiveness in areas with continuing transmission and receptivity. For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission. This becomes increasingly important as more countries move towards elimination.
David Kaslow and colleagues examine the progress in reasearch for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication and propose a research agenda.
Databáze: OpenAIRE
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