ATP release from the isolated perfused guinea pig heart in response to increased flow
| Autor: | Geoffrey Burnstock, Amanda J. Vials |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Langendorff heart medicine.medical_specialty Physiology Guinea Pigs Hemodynamics Vasodilation In Vitro Techniques Guinea pig Adenosine Triphosphate Internal medicine Coronary Circulation Medicine Animals business.industry Myocardium Heart Perfusion medicine.anatomical_structure Endocrinology Anesthesia Coronary vessel Circulatory system Vascular resistance Liberation Female Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | Journal of vascular research. 33(1) |
| ISSN: | 1018-1172 |
| Popis: | The Langendorff heart preparation was used to investigate the release of ATP from the guinea pig heart in response to increased coronary flow. The lucifer-in-luciferase firefly technique was used to determine levels of ATP in the perfusate. During periods of increased flow, ATP release was rapidly and significantly increased by at least tenfold the basal release. The pressure/flow ratio was reduced in increased-flow conditions suggesting that coronary vasodilatation had occurred. It is concluded that ATP release from the guinea pig heart is increased under raised-flow conditions. It is suggested that this ATP release induces coronary vasodilatation. |
| Databáze: | OpenAIRE |
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