Intracerebroventricular injection of stresscopin-related peptide enhances cardiovascular function in conscious rats
| Autor: | Yan-Hua Bing, Qing-Hua Jin, Ri-Long Piao, Ying-Jun Li, Ri Jin, Chun-Ping Chu, Mei-Zi Li, De-Lai Qiu, Hiroshi Kannan |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Corticotropin-Releasing Hormone Physiology Clinical Biochemistry Neuropeptide Blood Pressure Receptors Corticotropin-Releasing Hormone environment and public health Biochemistry Rats Sprague-Dawley Norepinephrine (medication) Norepinephrine Cellular and Molecular Neuroscience Endocrinology Heart Rate Internal medicine Heart rate medicine Animals Humans Urocortins Injections Intraventricular Gastric emptying business.industry Antagonist Area under the curve Peptide Fragments Rats Blood pressure business medicine.drug |
| Zdroj: | Regulatory Peptides. 186:7-11 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/j.regpep.2013.07.001 |
| Popis: | Stresscopin-related peptide (SRP), which is a member of the corticotropin-releasing factor (CRF) family, is a high-affinity ligand for the type 2 corticotropin-releasing factor receptor (CRF-R2) and is involved in stress-coping responses. Central treatment with SRP suppresses food intake, delays gastric emptying and decreases heat-induced edema, but the effects of central administration of SRP on the cardiovascular system are unclear. Here we examined the effects of intracerebroventricular (i.c.v.) administration of SRP on cardiovascular function, and compared the cardiovascular effects of SRP and stresscopin (SCP). Our results showed that i.c.v. administration of SRP (0.5nmol) increased mean arterial blood pressure (MABP) and heart rate (HR), but failed to increase plasma norepinephrine and epinephrine levels. Compared with an equivalent dose of SCP, the area under the curve (AUC) values for the changes in MABP and HR were significantly smaller with SRP, indicating that the cardiovascular effects of SRP were weaker than those mediated by SCP. Pre-treatment with a selective CRF-R2 antagonist, antisauvagine-30 (4nmol, i.c.v.) abolished the SRP and SCP induced changes in MABP and HR. These results indicate that central administration of SRP induces a weaker enhancement of cardiovascular function through CRF-R2 than that induced by SCP and that these effects are mediated without increasing plasma norepinephrine and epinephrine levels. |
| Databáze: | OpenAIRE |
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