Cellular expression of INK4a gene in cells of bladder cancer associated with human papilloma virus-16

Autor:	O. Yu. Shipulina, Volgareva Gm, L. S. Pavlova, L. E. Zavalishina, G. Frank, Kuevda Da, V. B. Matveev, D. A. Golovina, V. D. Ermilova, Yu. Yu. Andreeva, Shuling Cheng, Valeria A. Glazunova, Trofimova Ob, Cheban Nl
Rok vydání:	2010
Předmět:	Pathology medicine.medical_specialty Papillomavirus E7 Proteins Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology medicine Biomarkers Tumor Humans Urothelium neoplasms Gene Cyclin-Dependent Kinase Inhibitor p16 DNA Primers Cervical cancer Messenger RNA Human papillomavirus 16 Bladder cancer Reverse Transcriptase Polymerase Chain Reaction Cancer General Medicine Oncogene Proteins Viral medicine.disease Immunohistochemistry Repressor Proteins Urinary Bladder Neoplasms Papilloma Carcinogenesis
Zdroj:	Bulletin of experimental biology and medicine. 149(2)
ISSN:	1573-8221
Popis:	Hyperexpression of p16(INK4a) protein is an early marker of cervical cancer. Hyperexpression of INK4a gene encoding this protein at the level of mRNA and p16(INK4a) was detected in tumor cells of some patients with bladder cancer associated with human papilloma virus-16. However, in contrast to cervical cancer, this phenomenon in urothelial carcinomas does not correlate with expression of human papilloma virus-16 oncogenes E6 and E7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cb07d28aedc0f92b7791150ea5aab1 https://pubmed.ncbi.nlm.nih.gov/21113501 Zobrazit plný text záznamu Full text from SpringerLink