Disseminated fungal disease resistant to fluconazole treatment in a child with leukemia
| Autor: | Peter Gaustad, Eva Widing, Anders Glomstein, Tore G. Abrahamsen |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Antibiotics Drug resistance Microbiology Aspergillus fumigatus Candida krusei Medicine Humans Blood culture Fluconazole Fungemia Mycosis General Immunology and Microbiology biology medicine.diagnostic_test business.industry Drug Resistance Microbial General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma biology.organism_classification medicine.disease Infectious Diseases Child Preschool Immunology Female business medicine.drug |
| Zdroj: | Scandinavian journal of infectious diseases. 24(3) |
| ISSN: | 0036-5548 |
| Popis: | During a chemotherapy induced leukopenic period fluconazole (3 mg/kg/day i.v.) was administered as empiric antifungal treatment in a 5-year-old girl with leukemia and a presumed catheter infection due to Staphylococcus epidermidis. Despite intensive treatment with antibiotics and fluconazole the patient died. In one blood culture Candida krusei was isolated post mortem, and at autopsy Aspergillus fumigatus was found in multiple organs. Both fungi showed high MIC values to fluconazole. We feel that this drug should not be used when the possibility of a systemic infection with an unidentified fungus exists. |
| Databáze: | OpenAIRE |
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