Adamts18 modulates the development of the aortic arch and common carotid artery
Autor: | Thomas Wisniewski, Suying Dang, Yi-Hsuan Pan, Liya Wang, Xiaobing Yuan, Xiaohua Cao, Taojing Wu, Ning Yang, Shuai Ye, Tiantian Lu, Wei Zhang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Aortic arch Pathology medicine.medical_specialty Vascular smooth muscle Science Branchial arch 02 engineering and technology Biology Article Extracellular matrix 03 medical and health sciences developmental biology Cranial neural crest medicine.artery cell biology medicine Common carotid artery Multidisciplinary ADAMTS 021001 nanoscience & nanotechnology 030104 developmental biology medicine.anatomical_structure embryonic structures Carotid body 0210 nano-technology |
Zdroj: | iScience, Vol 24, Iss 6, Pp 102672-(2021) iScience |
ISSN: | 2589-0042 |
Popis: | Summary Members of a disintegrin and metalloproteinases with thrombospondin motif (ADAMTS) family have been implicated in various vascular diseases. However, their functional roles in early embryonic vascular development are unknown. In this study, we showed that Adamts18 is highly expressed at E11.5-E14.5 in cells surrounding the embryonic aortic arch (AOAR) and the common carotid artery (CCA) during branchial arch artery development in mice. Adamts18 deficiency was found to cause abnormal development of AOAR, CCA, and the third and fourth branchial arch appendages, leading to hypoplastic carotid body, thymus, and variation of middle cerebral artery. Adamts18 was shown to affect the accumulation of extracellular matrix (ECM) components, in particular fibronectin (Fn), around AOAR and CCA. As a result of increased Fn accumulation, the Notch3 signaling pathway was activated to promote the differentiation of cranial neural crest cells (CNCCs) to vascular smooth muscle cells. These data indicate that Adamts18-mediated ECM homeostasis is crucial for the differentiation of CNCCs. Graphical abstract Highlights • Adamts18 is highly expressed during the period of embryonic carotid artery formation • Adamts18 deficiency leads to abnormal AOAR, CCA, MCA branches and carotid appendages • Adamts18 deficiency changes the cerebral infarcted areas in mouse tMCAO model • Adamts18 affects the differentiation of CNCCs to VSMCs by modulating Notch3 pathway Cell biology; Developmental biology |
Databáze: | OpenAIRE |
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