Structural Phylogeny of Different Allergens May Reveal Common Epitopic Footprint
| Autor: | Anindya Sundar Panja, Anubhab Laha, Rajib Bandopadhyay |
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| Rok vydání: | 2021 |
| Předmět: |
Databases
Factual Protein Conformation In silico Fungus medicine.disease_cause Biochemistry Allergen Structural Biology Phylogenetics Pollen medicine Animals Humans Computer Simulation Amino Acid Sequence Food allergens Phylogeny Plant Proteins biology Bacteria Fungi General Medicine Allergens Immunoglobulin E biology.organism_classification Structural homology Evolutionary biology Fluprednisolone Food Hypersensitivity |
| Zdroj: | Protein and peptide letters. 28(10) |
| ISSN: | 1875-5305 |
| Popis: | Background: The incidence of allergy has been increasing at an alarming rate over the last few decades. Objective: Our present study aims to find out the structurally homologous motifs present in different proteinaceous allergens. Methods: Significant number of protein sequences and their corresponding structures of various pollen, fungal, bacterial, and food allergens were retrieved and the sequence and structural identity were analyzed. Results: Intra- and inter-sequence along with their structural analysis of the proteinaceous allergens revealed that no significant relationships exist among them. A few, but not the negligible number of high structural similarities, were observed within different groups of allergens from fungus, angiosperms, and animals (Aves and Mammalia). Conclusion: Our in silico study on thirty-six different allergens showed a significant level of structural similarities among themselves, regardless of their sequences. |
| Databáze: | OpenAIRE |
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