A mechanism for improved talc pleurodesis via foam delivery
| Autor: | Nicolas J. Alvarez, K M Laub, R A Coler, G W Laub, S Sexton, Thamires A. Lima, L Curtin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
pleurodesis
medicine.medical_treatment Chemistry Pharmaceutical Pharmaceutical Science 02 engineering and technology RM1-950 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Drug Stability medicine Animals Chemistry Talc pleurodesis technology industry and agriculture Hydrogels General Medicine 021001 nanoscience & nanotechnology malignant pleural effusions Talc Self-healing hydrogels Drug delivery rheology Delivery system Therapeutics. Pharmacology Rabbits 0210 nano-technology foam Pleurodesis Biomedical engineering Research Article |
| Zdroj: | Drug Delivery article-version (VoR) Version of Record Drug Delivery, Vol 28, Iss 1, Pp 733-740 (2021) |
| ISSN: | 1521-0464 1071-7544 |
| Popis: | Talcum powder is recognized as the leading drug for pleurodesis, a treatment of choice for malignant pleural effusions. Recently, it was shown that hydrogel foam delivery systems significantly enhanced the number of adhesions between the chest wall and the lung in a New Zealand rabbit model due to the sol-gel transition. However, many questions still remain regarding the cause of improved efficacy, such as: (1) Would only hydrogel foams improve the efficacy of talc pleurodesis? (2) Is it possible to achieve the same efficacy of hydrogels using non-hydrogel foams? 3) What are the physicochemical properties that can be correlated to the efficacy of talc pleurodesis? In this study, we use non-hydrogel foam formulations to determine the efficacy of pleurodesis. Foam stability and rheology of the formulations were correlated to adhesion formation. The results clearly suggest a correlation of pleurodesis efficacy to the viscosity and modulus of the foam delivery system. |
| Databáze: | OpenAIRE |
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