Protein phosphatases and their regulation in the control of mitosis
| Autor: | Tim Hunt, Satoru Mochida |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
CDK
Phosphatase Review Article Polo-like kinase Protein Serine-Threonine Kinases alpha-Endosulfine Biochemistry Substrate Specificity phosphatase Cyclin-dependent kinase Phosphoprotein Phosphatases Genetics Animals Humans Protein phosphorylation Protein Phosphatase 2 Enzyme Inhibitors Molecular Biology mitosis Protein-Serine-Threonine Kinases biology Kinase Greatwall Protein phosphatase 2 Cell cycle Phosphoproteins Cyclin-Dependent Kinases Cell biology Enzyme Activation biology.protein Signal Transduction |
| Zdroj: | EMBO reports. 13:197-203 |
| ISSN: | 1469-3178 1469-221X |
| DOI: | 10.1038/embor.2011.263 |
| Popis: | Cell cycle transitions depend on protein phosphorylation and dephosphorylation. Thediscovery of cyclin dependent kinases (CDKs) and their mode of activation by their cyclin partners explained many important aspects of cell cycle control. As the cell cycle is basically a series of recurrences of a defined set of events, protein phosphatases must obviously be as important as kinases. However, our knowledge about phosphatases lags well behind that of kinases. We still do not know exactly which phosphatase(s) is/are truly responsible for dephosphorylating CDK substrates, and we know very little about whether and how protein phosphatases are regulated. Here, we summarise our present understanding of the phosphatases that are important in the control of the cell cycle and pose the questions that need to be answered as regards the regulation of protein phosphatases. |
| Databáze: | OpenAIRE |
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