Obesity causes very low density lipoprotein clearance defects in low-density lipoprotein receptor-deficient mice
| Autor: | Kimberly R. Coenen, Marnie L. Gruen, Alyssa H. Hasty |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Very low-density lipoprotein
medicine.medical_specialty Ratón Endocrinology Diabetes and Metabolism Clinical Biochemistry Mice Obese Lipoproteins VLDL Biochemistry chemistry.chemical_compound Mice Internal medicine Hyperlipidemia medicine Animals cardiovascular diseases Obesity Receptor Molecular Biology Triglycerides Nutrition and Dietetics Triglyceride Chemistry Leptin food and beverages nutritional and metabolic diseases Lipase medicine.disease Mice Inbred C57BL Endocrinology Liver Receptors LDL LDL receptor lipids (amino acids peptides and proteins) Lipoprotein |
| Zdroj: | The Journal of nutritional biochemistry. 18(11) |
| ISSN: | 0955-2863 |
| Popis: | We have reported that obese leptin-deficient mice (ob/ob) lacking the low-density lipoprotein receptor (LDLR(-/-)) develop severe hyperlipidemia and spontaneous atherosclerosis. In the present study, we show that obese leptin receptor-deficient mice (db/db) lacking LDLR have a similar phenotype, even in the presence of elevated plasma leptin levels. We investigated the mechanism for the hyperlipidemia in obese LDLR(-/-) mice by comparing lipoprotein production and clearance rates in C57BL/6, ob/ob, LDLR(-/-) and ob/ob;LDLR(-/-) mice. Hepatic triglyceride production rates were equally increased ( approximately 1.4-fold, P |
| Databáze: | OpenAIRE |
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