Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats
| Autor: | İbrahim Kaplan, Mehmet Veysi Bahadir, Muzaffer Aydın Ketani, Mehmet Emin Yilmaz, Fatma Yilmaz Aydin, Zülfükar Yilmaz, Ali Kemal Kadiroglu, Berfin Kadiroğlu, Emre Aydin, Yasar Yildirim |
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| Přispěvatelé: | Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Aydın, Emre E., Yıldırım, Yaşar, Aydın, Fatma Yılmaz, Bahadır, Mehmet Veysi, Kaplan, İbrahim, Kadiroğlu, Berfin, Ketani, Muzaffer Aydın, Yılmaz, Zülfükar, Kadiroǧlu, Ali Kemal, Yılmaz, Mehmet Emin |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty RC955-962 030231 tropical medicine 030106 microbiology Inflammation Kidney medicine.disease_cause Gastroenterology Etanercept Rats Sprague-Dawley Sepsis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Arctic medicine. Tropical medicine Internal medicine Major Article medicine Animals biology Tumor Necrosis Factor-alpha business.industry Anti-Inflammatory Agents Non-Steroidal C-reactive protein Triggering receptor expressed on myeloid cells Malondialdehyde medicine.disease Rats Disease Models Animal Oxidative Stress Infectious Diseases medicine.anatomical_structure chemistry Oxidative stress biology.protein Parasitology Tumor necrosis factor alpha medicine.symptom business Injections Intraperitoneal medicine.drug TNF-alpha |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical Revista da Sociedade Brasileira de Medicina Tropical v.53 2020 Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) |
| Popis: | INTRODUCTION: Sepsis is an important cause of mortality and morbidity, and inflammatory response and oxidative stress play major roles underlying its pathophysiology. Here, we evaluated the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats. METHODS: Twenty-eight adult Sprague Dawley rats were classified into Control (Group 1), Sepsis (Group 2), Sepsis+Cefazolin (Group 3), and Sepsis+Cefazolin+Etanercept (Group 4) groups. Kidney tissue and serum samples were obtained for biochemical and histopathological investigations and examined for the C reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), triggering receptor expressed on myeloid cells (TREM), and malondialdehyde (MDA) levels. RESULTS: The levels of TNF-α, TREM, and MDA in serum and kidney samples were significantly higher in rats from sepsis group than in rats from control group (p < 0.05). Group 3 showed a significant reduction in serum levels of TNF-α, CRP, and TREM as compared with Group 2 (p < 0.05). Serum TNF-α, CRP, TREM, and MDA levels and kidney TNF-α and TREM levels were significantly lower in Group 4 than in Group 2 (p < 0.05). Serum TNF-α and TREM levels in Group 4 were significantly lower than those in Group 3, and histopathological scores were significantly lower in Group 3 and Group 4 than in Group 2 (p < 0.05). Histopathological scores of Group 4 were significantly lower than those of Group 3 (p < 0.05). CONCLUSIONS: Etanercept, a TNF-α inhibitor, may ameliorate sepsis-induced oxidative stress, inflammation, and histopathological damage. |
| Databáze: | OpenAIRE |
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