Recent Developments in Insect Steroid Metabolism

Autor: J. N. Kaplanis, M. J. Thompson, J. A. Svoboda, W. E. Robbins
Rok vydání: 1975
Předmět:
Zdroj: Annual Review of Entomology. 20:205-220
ISSN: 1545-4487
0066-4170
DOI: 10.1146/annurev.en.20.010175.001225
Popis: It is generally accepted that insects lack the capacity for de novo biosynthesis of the steroid nucleus, and to date all insects that have been examined critically have been shown to require an exogenous source of sterol to achieve normal growth, develop­ ment, and reproduction--except in those cases where associated symbiotes may provide a source of sterol. In all but two known exceptions, which will be discussed elsewhere in this chapter, this critical need for sterol can be satisfied by dietary cholesterol or some sterol that can be converted to cholesterol by the insect. Several reviews published since 1970 (17, 39, 42, 54, 56) provide detailed coverage on virtually every facet of the utilization and metabolism of steroids in insects. As the title implies, this chapter will be primarily devoted to a discussion of progress that has been made in this area of insect biochemistry since the last reviews on the subject were written. In the present chapter we will repeat that material covered in previous reviews only when it is required for background information, clarification, discus­ sion, or to emphasize the importance of an aspect that is being considered in detail. This review will be concerned with three major areas of insect steroid research: the metabolism and utilization of phytosterols and other neutral sterols; the in vivo metabolism of the ecdysones; and the in vitro metabolism of ecdysones. These were selected since most of the recent developments and advances in insect steroid metabolism have been in these three areas.
Databáze: OpenAIRE