Association of reduced maternal sHLA‐G5 isoform levels and elevated TNF‐α/IL‐4 cytokine ratio with Recurrent Pregnancy Loss: A study on South Indian women
| Autor: | Venkata Ramana Devi, Kethora Dirsipam, Mahalakshmi Goli, Parveen Jahan, Dhatri Madduru |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Abortion Habitual Adolescent medicine.medical_treatment Immunology India Inflammation Immune tolerance Andrology Young Adult Pregnancy Humans Protein Isoforms Medicine Interleukin 4 HLA-G Antigens Fetus Tumor Necrosis Factor-alpha business.industry Pregnancy Outcome General Medicine medicine.disease Cytokine Solubility Case-Control Studies Multivariate Analysis Female Tumor necrosis factor alpha Interleukin-4 Sample collection medicine.symptom business Biomarkers |
| Zdroj: | Scandinavian Journal of Immunology. 94 |
| ISSN: | 1365-3083 0300-9475 |
| DOI: | 10.1111/sji.13095 |
| Popis: | Inflammation is of critical importance in successful implantation during pregnancy. However, the establishment of maternal immune tolerance towards semi-allograft foetus is more exigent and is achieved predominantly by human leukocyte antigen-G (HLA-G) isoforms with a special emphasis on soluble HLA-G5 (sHLA-G5). Constant inflammation and lack of resolution by anti-inflammatory milieu, due to aberrant expression of critical immunoregulatory molecules such as sHLA-G5 and dysfunctional T helper cells 1 and 2 (Th1-Th2) cytokine shift, can lead to adverse pregnancy outcomes including recurrent pregnancy loss (RPL). Serum samples of 270 pregnant women (135 healthy parous and 135 with a history of RPL) were evaluated for the concentrations of sHLA-G5, interleukin-4 (IL-4) and tumour necrosis factor-alpha (TNF-α) using sandwich enzyme-linked immunosorbent assay (ELISA) and found elevated levels of sHLA-G5 and IL-4 in controls and higher TNF-α levels and TNF-α:IL-4 ratio in patients (P |
| Databáze: | OpenAIRE |
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