Comparison of Responses to Influenza A/New Jersey /76-A/Victoria/75 Virus Vaccine Administered Intradermally or Subcutaneously to Adults with Chronic Respiratory Disease
| Autor: | F. Alexander Herbert, R. P. Bryce Larke, Edythe L. Markstad |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Adolescent Injections Intradermal Injections Subcutaneous Respiratory Tract Diseases Orthomyxoviridae Antibodies Viral medicine.disease_cause Virus Antigen Influenza A virus Humans Immunology and Allergy Medicine Aged Hemagglutination assay biology business.industry Viral Vaccine Age Factors Middle Aged biology.organism_classification Virology Vaccination Infectious Diseases Influenza Vaccines Chronic Disease Immunology biology.protein Antibody business |
| Zdroj: | Journal of Infectious Diseases. 140:234-238 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/140.2.234 |
| Popis: | Serum HAI (hemagglutination inhibition) antibody responses were compared in two groups of 70 age-matched patients (age range, 17 to 82 years) who were vaccinated with bivalent influenza A/New Jersey/76-A/Victoria/75 whole-virus vaccine. The group that was vaccinated intradermally received 40 chick cell-agglutinating units of each viral antigen in 0.1 ml, and the group that was vaccinated subcutaneously received 200 chick cell-agglutinating units of each antigen in 0.5 ml. The serum HAI antibody response to A/New Jersey/76 antigen was significantly higher in the group that was vaccinated subcutaneously; this difference was particularly evident in patients less than or equal to 50 years old. The serologic response to A/Victoria/75 antigen did not differ significantly between the two groups. Levels of antibody before vaccination indicated previous widespread exposure of patients to influenza A/Victoria/75 virus, but not to influenza A/New Jersey/76 virus. Such differences in prior immunologic experience with a particular strain of influenza virus probably determine whether the intradermal route of vaccination is as effective as, or inferior to, the subcutaneous route. |
| Databáze: | OpenAIRE |
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