Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
| Autor: | Kevin A. Johnson, E. Dixon, Ian G Mackey, Jiang-Ti Kong |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Central Nervous System
Pain Threshold Computer science media_common.quotation_subject General Chemical Engineering Population Summation General Biochemistry Genetics and Molecular Biology Issue 120 thermal 03 medical and health sciences temporal summation 0302 clinical medicine Perception second pain medicine Humans conditioned pain modulation 030212 general & internal medicine education Pain Measurement media_common contact-heat evoked potential stimulator (CHEPS) education.field_of_study Postsynaptic Potential Summation General Immunology and Microbiology General Neuroscience Cold pressor test Chronic pain cold pressor test Pain Perception medicine.disease Nociception endogenous analgesia Facilitation Chronic Pain Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Visualized Experiments : JoVE |
| ISSN: | 1940-087X |
| DOI: | 10.3791/54452-v |
| Popis: | Central facilitation and modulation of incoming nociceptive signals play an important role in the perception of pain. Disruption in central pain processing is present in many chronic pain conditions and can influence responses to specific therapies. Thus, the ability to precisely describe the state of central pain processing has profound clinical significance in both prognosis and prediction. Because it is not practical to record neuronal firings directly in the human spinal cord, surrogate behavior tests become an important tool to assess the state of central pain processing. Dynamic QST is one such test, and can probe both the ascending facilitation and descending modulation of incoming nociceptive signals via TS and CPM, respectively. Due to the large between-individual variability in the sensitivity to noxious signals, standardized TS and CPM tests may not yield any meaningful data in up to 50% of the population due to floor or ceiling effects. We present methodologies to individualize TS and CPM so we can capture these measures in a broader range of individuals than previously possible. We have used these methods successfully in several studies at the lab, and data from one ongoing study will be presented to demonstrate feasibility and potential applications of the methods. |
| Databáze: | OpenAIRE |
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