Evaluation of the appropriateness of composite disease activity measures for assessment of psoriatic arthritis
| Autor: | Stephan Pflugbeil, Daniel Aletaha, Tanja Stamm, Valerie Nell-Duxneuner, Josef S. Smolen, Klaus P Machold |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Immunology Arthritis General Biochemistry Genetics and Molecular Biology Disability Evaluation Psoriatic arthritis Rheumatology Pain assessment Psoriasis Internal medicine medicine Humans Immunology and Allergy Reactive arthritis business.industry Arthritis Psoriatic medicine.disease Arthralgia Clinical trial C-Reactive Protein Principal component analysis Physical therapy Joints Epidemiologic Methods business Biomarkers |
| Zdroj: | Annals of the Rheumatic Diseases. 69:546-549 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/ard.2009.117945 |
| Popis: | ObjectiveSpecific composite indices assessing disease activity in psoriatic arthritis (PsA) have not yet been sufficiently validated. The objective of this study was to identify instruments best reflecting disease activity in PsA.MethodsMeasures for inclusion in clinical trials, as recommended by the OMERACT-7/8 PsA workshops, were assessed. A principal component analysis (PCA) was performed with cross-sectional data of 105 patients with PsA to identify a minimal set of important dimensions for a disease activity assessment tool for PsA. This was compared with components contained in existing composite indices.ResultsThe PCA revealed four principal components best reflecting disease activity. The first contained patient global and pain assessment; the second contained 66/68 swollen and tender joint counts as main variables; C-reactive protein (CRP) best loaded to the third component; and the fourth was loaded by skin assessment but did not reach significance. When comparing the three significant principal components with items of established composite measures, they were best covered by the Disease Activity Index for Reactive Arthritis (DAREA) which comprises patient pain and global assessments, 66/68 joint counts and CRP.ConclusionAmong the currently available indices used in arthritic conditions, the DAREA best reflects the domains found to be important in PsA. |
| Databáze: | OpenAIRE |
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