Antibody assays suitable for assessing immune responses to live varicella vaccine

Autor:	Timothy L. Schofield, E H Wasmuth, Barbara J. Kuter, David L. Krah, Philip J. Provost, William J. Miller, D H Morton, Ronald W. Ellis, C J White
Rok vydání:	1991
Předmět:	Herpesvirus 3 Human Varicella vaccine viruses Fluorescent Antibody Technique Enzyme-Linked Immunosorbent Assay medicine.disease_cause Antibodies Viral Virus Chickenpox Vaccine Viral Proteins Antigen Neutralization Tests medicine Humans Neutralizing antibody Antigens Viral Glycoproteins integumentary system General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Varicella zoster virus virus diseases Viral Vaccines Virology Infectious Diseases Evaluation Studies as Topic Immunology Humoral immunity biology.protein Molecular Medicine Antibody business
Zdroj:	Vaccine. 9(2)
ISSN:	0264-410X
Popis:	An enzyme-linked immunosorbent assay for antibodies to varicella-zoster virus (VZV), using purified viral glycoproteins as antigen (gpELISA), was compared with other assays for measuring vaccine-induced antibody responses. The gpELISA was more sensitive than conventional assays, proved highly specific for VZV and agreed well with an assay for neutralizing antibody activity. It was successfully applied to large-scale testing of live varicella vaccine in humans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b75334610a2bf3e7b01d019ff48733 https://pubmed.ncbi.nlm.nih.gov/1647574 Zobrazit plný text záznamu