Regulation of lymphocyte transformation responses to phytohaemagglutinin, concanavalin A or lipopolysaccharide by normal serum
| Autor: | D. Perdoux, D. Reiss, P.J. Neveu |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Lipopolysaccharide Lymphocyte Guinea Pigs Heterologous chemical and pharmacologic phenomena Spleen In Vitro Techniques Biology Lymphocyte Activation Guinea pig chemistry.chemical_compound Internal medicine Concanavalin A medicine Animals Humans Phytohemagglutinins General Environmental Science Phytohaemagglutinin Cell Membrane Albumin General Medicine Blood Physiological Phenomena medicine.anatomical_structure Endocrinology chemistry biology.protein General Earth and Planetary Sciences Cattle Female Mitogens |
| Zdroj: | Annales de l'Institut Pasteur / Immunologie. 133:69-82 |
| ISSN: | 0769-2625 |
| Popis: | Lymphocyte blastogenesis of guinea-pig spleen cells induced by various loses of phytohaemagglutinin (PHA), concanavalin A (conA) or lipopolyaccharide (LPS) was assayed in the absence or in the presence of normal guinea-pig serum, foetal calf serum or heterologous albumin or gamma-globulins. Opposute effects of diluted and of concentrated sera were observed in blastogenesis induced either by PHA or by ConA: high concentrations inhibited blastogenesis whereas low concentrations enhanced mitogenesis. Homologous serum inhibited LPS-induced blastogenesis whatever the concentration used. These results could be explained by the interaction of serum with the membrane of lymphocytes stimulated by ConA, PHA or LPS. Furthermore sera could interfere with ConA. The implications of these experiments are discussed. |
| Databáze: | OpenAIRE |
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