The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation
| Autor: | Irinel Popescu, Daniela Lixandru, Radu Albulescu, Veronica Ilie, Ioan V Matei, Sarah Ferber, Irit Meivar-Levy, Ioana R Florea, Simona Dima |
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| Rok vydání: | 2021 |
| Předmět: |
Metabolic state
Adult Embryology medicine.medical_specialty Lineage (genetic) Adolescent Biomedical Engineering 030209 endocrinology & metabolism 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Child Pancreas 030304 developmental biology Cell Proliferation 0303 health sciences Human liver business.industry Transdifferentiation Middle Aged medicine.disease In vitro medicine.anatomical_structure Endocrinology Liver Child Preschool Liver donors Cell Transdifferentiation business |
| Zdroj: | Regenerative medicine. 16(1) |
| ISSN: | 1746-076X |
| Popis: | Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors’ heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3–60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics. |
| Databáze: | OpenAIRE |
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