Diagnostic efficacy of SonoVue, a second generation contrast agent, in the assessment of extracranial carotid or peripheral arteries using colour and spectral Doppler ultrasound: a multicentre study
| Autor: | C. Pezzoli, Paul S. Sidhu, Anthony Davies, S. Karakagil, J.B. Llull, F. Cattin, David O. Cosgrove, D.A. Legemate, D.D. Do, A. Spinazzi, P.L. Allan, J. Langholz, Alberto Martegani |
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| Přispěvatelé: | Amsterdam Cardiovascular Sciences, Surgery |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Arterial disease Ultrasonography Doppler Transcranial media_common.quotation_subject Spectral doppler Sulfur Hexafluoride Sensitivity and Specificity symbols.namesake Double-Blind Method Medicine Contrast (vision) Humans Radiology Nuclear Medicine and imaging Ultrasonography Doppler Color Phospholipids media_common Aged Aged 80 and over Peripheral Vascular Diseases Cross-Over Studies Dose-Response Relationship Drug business.industry Ultrasound General Medicine Middle Aged Crossover study Peripheral symbols Ultrasound imaging Female Radiology business Artifacts Doppler effect |
| Zdroj: | British journal of radiology, 79(937), 44-51. British Institute of Radiology |
| ISSN: | 0007-1285 |
| Popis: | The purpose of this study was to demonstrate the improvement in diagnostic quality and diagnostic accuracy of SonoVue microbubble contrast-enhanced ultrasound (CE-US) versus unenhanced ultrasound imaging during the investigation of extracranial carotid or peripheral arteries. 82 patients with suspected extracranial carotid or peripheral arterial disease received four SonoVue doses (0.3 ml, 0.6 ml, 1.2 ml and 2.4 ml) with Doppler ultrasound performed before and following each dose. Diagnostic quality of the CE-US examinations was evaluated off-site for duration of clinically useful contrast enhancement, artefact effects and percentage of examinations converted from non-diagnostic to diagnostic. Accuracy, sensitivity and specificity were assessed as agreement of CE-US diagnosis evaluated by an independent panel of experts with reference standard modality. The median duration of clinically useful signal enhancement significantly increased with increasing SonoVue doses (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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