OCT is not useful for detection of minimal diabetic retinopathy in type 1 diabetes
| Autor: | S. Carita, Gaetano Lodato, Raffaella Morreale, Marco Calogero Amato, Alessandro Ciresi, Aldo Galluzzo, Fausto Di Giovanna, Carla Giordano, Daniele Morreale |
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| Přispěvatelé: | Ciresi, A., Amato, M., MORREALE BUBELLA, D., MORREALE BUBELLA, R., Di Giovanna, F., Carità, S., Lodato, G., Galluzzo, A., Giordano, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Gastroenterology Retina Settore MED/13 - Endocrinologia Young Adult Endocrinology Optical coherence tomography (OCT) type 1 diabetes (T1D) minimal diabetic retinopathy (MDR) retinal thickness (RT) Predictive Value of Tests Internal medicine Diabetes mellitus Internal Medicine medicine Humans Hypoglycemic Agents Insulin Macular edema Type 1 diabetes Diabetic Retinopathy medicine.diagnostic_test business.industry Settore MED/30 - Malattie Apparato Visivo Fundus photography General Medicine Diabetic retinopathy medicine.disease Radiography Diabetes Mellitus Type 1 Predictive value of tests Microalbuminuria Female business Medical Futility Tomography Optical Coherence Retinopathy |
| Popis: | Optical coherence tomography (OCT) has been proven useful in measuring retinal thickness (RT) in patients with diabetes, although with discordant results in different studies. We examined RT in patients with type 1 diabetes (T1D) with or without minimal diabetic retinopathy (MDR) to test whether OCT is able to identify early retinal changes and potential correlations with metabolic parameters. RT of 102 patients with T1D (53 females, 49 males, aged 27.03 +/- 7.4 years) and of 42 healthy controls was examined, with analysis of nine different sectors (fovea, four pericentral and four peripheral sectors). According to the results of basal fundus photography, patients were divided into two groups, without MDR (48 cases) and with MDR (54 cases). Patients with proliferative DR or macular edema were excluded. No difference was found between patients with or without MDR and the control group for all OCT parameters investigated. Mean HbA1c of the last 5 years (P < 0.001), microalbuminuria (P = 0.002), total (P = 0.046) and LDL cholesterol (P = 0.007) and triglyceride (P < 0.001) levels were higher in patients with MDR, along with higher prevalence of hypertension (P = 0.013), younger age at diagnosis (P = 0.018) and longer diabetes duration (P < 0.001) with regard to the patients without MDR and controls, although no significant correlation between these parameters and RT was found. Our study suggests that MDR without macular edema in patients with T1D cannot be detected with OCT. Therefore, the conventional diagnostic methods are mandatory to detect early DR. |
| Databáze: | OpenAIRE |
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