Management of Xerostomia in Older Patients
| Autor: | Michel Salom, Stéphane Mouly, Philip M. Preshaw, Yves Tillet, Stéphane Desjonquères, Anne-Claude Coudert, Jean-François Bergmann, Frantz Oberli |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Glycerol
Male Saliva medicine.medical_specialty Endpoint Determination Visual analogue scale Administration Oral Dentistry Xerostomia law.invention Double-Blind Method Randomized controlled trial Tongue Oral administration law Surveys and Questionnaires Internal medicine medicine Clinical endpoint Mucositis Humans Pharmacology (medical) Oral mucosa Aged Lubricants Aerosols Aged 80 and over Mouth business.industry medicine.disease Long-Term Care Hospitalization Pharmaceutical Solutions stomatognathic diseases Treatment Outcome medicine.anatomical_structure Female Geriatrics and Gerontology business |
| Zdroj: | Drugs & Aging. 24:957-965 |
| ISSN: | 1170-229X |
| DOI: | 10.2165/00002512-200724110-00007 |
| Popis: | Xerostomia is a subjective sensation of mouth dryness that may frequently occur in older patients.To compare the clinical efficacy and acceptability of a new oxygenated glycerol triester (OGT) oral spray taken five times daily with that of a commercially available saliva substitute Saliveze in the treatment of xerostomia.Forty-one institutionalised patients (28 women, 13 men; mean age 84 +/- 7 years) were randomly assigned to receive either OGT or Saliveze in a 2-week, randomised, parallel-group study. Clinical assessment of xerostomia included evaluation of mouth dryness using a self-rated, 10cm long visual analogue scale (VAS), objective assessment of oral tissue condition using a four-point ordinal scale and subjective assessment of symptoms of xerostomia using dichotomous responses to a questionnaire. The primary endpoint was the day (D) 14 patient-based mouth dryness score measured on a self-rated VAS.At D14, OGT resulted in significantly greater efficacy with respect to mouth dryness (mean between-treatment difference 2.1 +/- 0.1, 95% CI 1.9, 2.3; p = 0.001), swallowing difficulty (1.8 +/- 0.3, 95% CI 1.5, 2.1; p = 0.001), speech difficulty (1.1 +/- 0.2, 95% CI 1.0, 2.4; p = 0.04) and overall sensation of symptom relief (2.7 +/- 1.2, 95% CI 1.9, 3.8; p = 0.001). Objective assessment of oral tissues also showed significantly better improvement with OGT spray with respect to dryness (p = 0.01), stickiness (p = 0.005) and dullness (p = 0.001) of oral mucosa; severity of mucositis (p = 0.01); and thickening of the tongue (p = 0.03). A significant difference in taste acceptability was also noted in favour of OGT (1.4 +/- 0.6, 95% CI 1.2, 1.9; p = 0.04).OGT lubricant oral spray was superior to Saliveze in improving xerostomia and oral tissue condition in older institutionalised patients. |
| Databáze: | OpenAIRE |
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