The Physicochemical Characterization and In Vitro/In Vivo Evaluation of Natural Surfactants-based Emulsions as Vehicles for Diclofenac Diethylamine

Autor: Gordana Vuleta, Nada Vučinić-Milanković, Slavica Vučinić, Snežana Savić
Rok vydání: 2007
Předmět:
Diclofenac
Diethylamines
Chemistry
Pharmaceutical
Skin Absorption
Pharmaceutical Science
Excipient
02 engineering and technology
liquid-crystalline gel network
Dosage form
Surface-Active Agents
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Glucosides
Pulmonary surfactant
Stearate
Stearates
Drug Discovery
Amphiphile
medicine
Humans
Organic chemistry
sorbitan stearate & sucrose cocoate
Pharmacology
Diethylamine
diclophenac diethylamine release
Chromatography
Anti-Inflammatory Agents
Non-Steroidal
Organic Chemistry
Sorbitan
021001 nanoscience & nanotechnology
droplet size analysis
Liquid Crystals
chemistry
Emulsion
Emulsions
rheology
cetearyl alcohol & cetearyl glycoside
Fatty Alcohols
Rheology
0210 nano-technology
medicine.drug
Zdroj: Drug Development and Industrial Pharmacy
ISSN: 1520-5762
0363-9045
DOI: 10.1080/03639040601150179
Popis: Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug - diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and rheological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.
Databáze: OpenAIRE
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