Incidence of cardiovascular disease and its associated risk factors in at-risk men and women in the United Arab Emirates: a 9-year retrospective cohort study

Autor: Romona D. Govender, Dybesh Regmi, Saif Al-Shamsi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Blood Glucose
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Blood Pressure
030204 cardiovascular system & hematology
0302 clinical medicine
Risk Factors
Epidemiology
030212 general & internal medicine
Stroke
education.field_of_study
Incidence (epidemiology)
Incidence
Hazard ratio
Smoking
Middle Aged
Cardiovascular disease
Cholesterol
Cardiovascular Diseases
Hypertension
Female
Kidney Diseases
Cardiology and Cardiovascular Medicine
Research Article
Glomerular Filtration Rate
Adult
medicine.medical_specialty
Population
United Arab Emirates
Risk Assessment
03 medical and health sciences
Sex Factors
Diabetes mellitus
Internal medicine
medicine
Diabetes Mellitus
Humans
cardiovascular diseases
education
Aged
Dyslipidemias
Retrospective Studies
Glycated Hemoglobin
business.industry
Cholesterol
HDL
Retrospective cohort study
medicine.disease
Myocardial infarction
Blood pressure
lcsh:RC666-701
Acute peripheral arterial occlusion
business
Biomarkers
Zdroj: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-9 (2019)
ISSN: 1471-2261
Popis: Background Cardiovascular disease (CVD) is the leading cause of mortality worldwide; however, the epidemiology of CVD among nationals from the United Arab Emirates (UAE) remains unknown. This study aimed to estimate the 9-year incidence rate of CVD and determine the risk factors associated with CVD among UAE nationals at high cardiovascular risk. In addition, we investigated whether sex was an important modifier of the risk factors associated with incident CVD in this population. Methods A retrospective cohort study was conducted on 977 subjects, including 492 women, aged ≥18 years, who did not have histories of CVD, and who had ≥1 CVD risk factors. Multivariable Cox proportional hazards regression analyses stratified by sex were used to examine the predictors of major CVD events, namely, myocardial infarction (MI), stroke, and acute peripheral arterial occlusion. Results During a median follow-up period of 8.9 years, the incidence rate of major CVD was 12.7 per 1000 person-years (95% confidence interval [CI] 10.4–15.4), and among men and women were 16.8 (95% CI 12.9–21.4) and 9.0 (95% CI 6.4–12.4) per 1000 person-years, respectively. Major CVD and MI were significantly more frequent among men than women, and the stroke and acute peripheral arterial occlusion rates were similar for both sexes. Multivariable Cox analyses showed that the systolic blood pressure, estimated glomerular filtration rate, and serum glycosylated hemoglobin A1c level were strong predictors of major CVD in both sexes. Among women, the total cholesterol (TC)-to-high-density lipoprotein-cholesterol (HDL-C) ratio (hazard ratio [HR] 1.44, 95% CI 1.02–2.04) was an additional independent predictor of major CVD. Age (HR 1.50, 95% CI 1.19–1.89) and a history of smoking (HR 1.80, 95% CI 1.07–3.02) were significant risk factors associated with major CVD in men. Conclusions Among high-risk UAE nationals who did not have histories of CVD, the risk of major CVD was associated with high systolic blood pressure, a low estimated glomerular filtration rate, and poorly controlled diabetes. The high TC-to-HDL-C ratios, especially among women, and smoking among men, are modifiable risk factors that should be managed aggressively. Electronic supplementary material The online version of this article (10.1186/s12872-019-1131-2) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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