O-Linked-N-Acetylglucosamine Cycling and Insulin Signaling Are Required for the Glucose Stress Response in Caenorhabditis elegans
| Autor: | Michelle R. Bond, John A. Hanover, Tetsunari Fukushige, Michael W. Krause, Salil Ghosh, Dona C. Love, Gayani R. Weerasinghe, Michelle A. Mondoux |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Time Factors Blotting Western Carbohydrates Investigations N-Acetylglucosaminyltransferases Acetylglucosamine Fight-or-flight response Stress Physiological Genetics Animals Insulin Glucose homeostasis Caenorhabditis elegans Caenorhabditis elegans Proteins Dose-Response Relationship Drug biology Reproduction O linked n acetylglucosamine biology.organism_classification Lipids Receptor Insulin beta-N-Acetylhexosaminidases Insulin receptor Glucose Biochemistry Larva Mutation biology.protein Female Signal transduction Cycling Homeostasis Signal Transduction |
| Zdroj: | Genetics. 188:369-382 |
| ISSN: | 1943-2631 |
| DOI: | 10.1534/genetics.111.126490 |
| Popis: | In a variety of organisms, including worms, flies, and mammals, glucose homeostasis is maintained by insulin-like signaling in a robust network of opposing and complementary signaling pathways. The hexosamine signaling pathway, terminating in O-linked-N-acetylglucosamine (O-GlcNAc) cycling, is a key sensor of nutrient status and has been genetically linked to the regulation of insulin signaling in Caenorhabditis elegans. Here we demonstrate that O-GlcNAc cycling and insulin signaling are both essential components of the C. elegans response to glucose stress. A number of insulin-dependent processes were found to be sensitive to glucose stress, including fertility, reproductive timing, and dauer formation, yet each of these differed in their threshold of sensitivity to glucose excess. Our findings suggest that O-GlcNAc cycling and insulin signaling are both required for a robust and adaptable response to glucose stress, but these two pathways show complex and interdependent roles in the maintenance of glucose–insulin homeostasis. |
| Databáze: | OpenAIRE |
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