Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men

Autor:	Gabrielle G.M. Pinkse, Bart O. Roep, A. R. Van Der Slik, Wendy W. Unger, Ferry Ossendorp, Michel G.D. Kester, Jan W. Drijfhout, D.V. Serreze, S. MULDER-van der Kracht
Rok vydání:	2007
Předmět:	endocrine system CD8 Antigens Nod Autoantigens General Biochemistry Genetics and Molecular Biology Epitope Epitopes Islets of Langerhans Mice History and Philosophy of Science Antigen Cytotoxic T cell Animals Humans geography geography.geographical_feature_category biology General Neuroscience Proteins Islet Disease Models Animal Diabetes Mellitus Type 1 Immunology biology.protein Glucose-6-Phosphatase Beta cell Glucose 6-phosphatase CD8
Zdroj:	Annals of the New York Academy of Sciences. 1103
ISSN:	0077-8923
Popis:	Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin-producing beta cells by autoreactive T cells. CD8(+) T cells play an essential role in this beta cell destruction. However, little is known about the target antigens of CD8(+) T cells in human T1D patients. The aim of this study was to assess whether an epitope derived from the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), IGRP(265-273,) which has recently been identified as a target in non-obese diabetic (NOD) mice and is fully homologous to the human epitope, is a target of human diabetogenic CD8(+) T cells. We isolated a human CD8 T cell clone against this epitope, which confirms that this IGRP epitope is shared across species.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a9f1f0de192c8b0c0e0c8acd17cd55 https://pubmed.ncbi.nlm.nih.gov/17376840 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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