Can preoperative neutrophil to lymphocyte, lymphocyte to monocyte, or platelet to lymphocyte ratios differentiate glioblastoma from brain metastasis?
| Autor: | Oguz Baran, Taner Tanriverdi, Rahsan Kemerdere, Taha Sukru Korkmaz, Ahmet Kayhan |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Pathology Neutrophils Lymphocyte Monocytes Neurosurgical Procedures Metastasis 0302 clinical medicine glioma Platelet 030212 general & internal medicine Lymphocytes Neoplasm Metastasis Brain Neoplasms General Medicine Middle Aged platelet–lymphocyte ratio medicine.anatomical_structure 030220 oncology & carcinogenesis Preoperative Period Female medicine.symptom Research Article Blood Platelets medicine.medical_specialty neutrophil–lymphocyte ratio Observational Study Inflammation Diagnosis Differential 03 medical and health sciences medicine Biomarkers Tumor platelet-lymphocyte ratio Humans metastasis Lymphocyte Count neutrophil-lymphocyte ratio Retrospective Studies business.industry Platelet Count Monocyte lymphocyte–monocyte ratio Retrospective cohort study medicine.disease body regions business Glioblastoma lymphocyte-monocyte ratio Brain metastasis Follow-Up Studies |
| Zdroj: | Medicine |
| Popis: | This retrospective analysis of patients aims to show the blood levels of preoperative inflammatory markers in patients with glioblastoma and brain metastasis and to provide the diagnostic accuracy of the neutrophil-lymphocyte (NLR), lymphocyte-monocyte (LMR), and platelet-lymphocyte (PLR) ratios between the 2 groups of patients.The retrospective reviews of the neutrophil, lymphocyte, monocyte, and platelet counts were analyzed in 80 patients with newly diagnosed glioblastoma and 70 patients with brain metastasis. The NLR, LMR, and PLR were calculated in each group. The differences in all the parameters were compared between the 2 groups.Although the neutrophil, monocyte, and platelet counts were higher and the lymphocyte count was lower in patients with metastasis, the difference was not significant. A significantly higher PLR (P=.004) and a lower LMR (P=.01) were found in patients with brain metastasis. Although both PLR and LMR had diagnostic accuracy in differentiating glioblastoma from brain metastasis, LMR showed the highest diagnostic accuracy. NLR showed no diagnostic accuracy.Systemic inflammation is more severe in glioblastoma than in brain metastasis, and LMR is more sensitive and/or specific than PLR in differentiating glioblastoma from brain metastasis. Therefore, LMR (less likely PLR) can be used as an index for differentiating between glioblastoma and brain metastasis before surgery. Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. |
| Databáze: | OpenAIRE |
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