Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men

Autor: Jørgen Arendt Jensen, Pirjo Nuutila, Roeland J.W. Middelbeek, Jukka Kemppainen, Mueez U Din, Juhani Knuuti, Jarna C. Hannukainen, Kumail K. Motiani, Virva Saunavaara, Anna M. Savolainen, Laurie J. Goodyear, Eliisa Löyttyniemi, Piryanka Motiani, Joonas J. Eskelinen, Kirsi A. Virtanen, Riitta Parkkola, Kari K. Kalliokoski
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
positron emission tomography
Endocrinology
Diabetes and Metabolism
Glucose uptake
medicine.medical_treatment
free fatty acid uptake
030209 endocrinology & metabolism
White adipose tissue
Fatty Acids
Nonesterified
Interval training
03 medical and health sciences
0302 clinical medicine
Endocrinology
Insulin resistance
Oxygen Consumption
Adipose Tissue
Brown
Internal medicine
Brown adipose tissue
Internal Medicine
Medicine
Humans
Insulin
Muscle
Skeletal
ta315
Exercise
2. Zero hunger
business.industry
VO2 max
brown adipose tissue
Original Articles
Middle Aged
ta3121
medicine.disease
Quadriceps femoris muscle
glucose uptake
030104 developmental biology
medicine.anatomical_structure
Glucose
Health
Original Article
Insulin Resistance
business
exercise training
Zdroj: Diabetes, Obesity & Metabolism
ISSN: 1462-8902
DOI: 10.1111/dom.12947
Popis: AIMS To test the hypothesis that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) improve brown adipose tissue (BAT) insulin sensitivity. PARTICIPANTS AND METHODS Healthy middle-aged men (n = 18, age 47 years [95% confidence interval {CI} 49, 43], body mass index 25.3 kg/m2 [95% CI 24.1-26.3], peak oxygen uptake (VO2peak ) 34.8 mL/kg/min [95% CI 32.1, 37.4] ) were recruited and randomized into six HIIT or MICT sessions within 2 weeks. Insulin-stimulated glucose uptake was measured using 2-[18 F]flouro-2-deoxy-D-glucose positron-emission tomography in BAT, skeletal muscle, and abdominal and femoral subcutaneous and visceral white adipose tissue (WAT) depots before and after the training interventions. RESULTS Training improved VO2peak (P = .0005), insulin-stimulated glucose uptake into the quadriceps femoris muscle (P = .0009) and femoral subcutaneous WAT (P = .02) but not into BAT, with no difference between the training modes. Using pre-intervention BAT glucose uptake, we next stratified subjects into high BAT (>2.9 µmol/100 g/min; n = 6) or low BAT (
Databáze: OpenAIRE
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