Modulation of the antibiotic activity against multidrug resistant strains of 4-(phenylsulfonyl) morpholine
| Autor: | Henrique Douglas Melo Coutinho, Diniz M. Sena, T.A. Toledo, Ricardo Ferreira Bento, Irwin Rose Alencar de Menezes, Fernando Gomes Figueredo, Cícera J.M. Cassiano, Alexandre Magno Rodrigues Teixeira, Luiz Everson da Silva, Maria T.A. Oliveira |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Klebsiella pneumoniae medicine.drug_class Antibiotics Antimicrobial agent Biology medicine.disease_cause Microbiology 4-(Phenylsulfonyl) morpholine 03 medical and health sciences chemistry.chemical_compound Minimum inhibitory concentration Morpholine medicine Modulation Agricultural and Biological Sciences(all) Pseudomonas aeruginosa biology.organism_classification Antimicrobial Multiple drug resistance 030104 developmental biology chemistry Amikacin Original Article Microbial resistance General Agricultural and Biological Sciences medicine.drug |
| Zdroj: | Saudi Journal of Biological Sciences. (1):34-38 |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2015.02.001 |
| Popis: | The compound 4-(Phenylsulfonyl) morpholine belongs to the class of sulfonamides, which are widely used in the treatment of a large number of diseases caused by microorganisms. This compound has a morpholine group, which is also known for its antimicrobial properties. The aim of the present study was to investigate the antimicrobial and modulating activity of 4-(Phenylsulfonyl) morpholine against standard and multi-resistant strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and strains of the fungi Candida albicans, C. tropicalis and C. krusei. Antimicrobial activity was assessed based on the minimum inhibitory concentration (MIC) using the microdilution method. MIC was ⩾1024μg/mL for all microorganisms. Regarding modulating activity, the most representative effect occurred with the combination of 4-(Phenylsulfonyl) morpholine at a concentration of 128μg/mL (MIC 1/8) and amikacin against P. aeruginosa 03, with a reduction in MIC from 312.5 to 39.06μg/mL. |
| Databáze: | OpenAIRE |
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