Functional improvements to 6 months of physical activity are not related to changes in size or density of multiple lower-extremity muscles in mobility-limited older individuals
| Autor: | Afsaneh Koochek, Tommy Cederholm, Elisabeth Skoglund, Tommy R. Lundberg, Dylan R. Kirn, Roger A. Fielding, Hans E. Berg, Davis A. Englund, Åsa von Berens, Thomas Gustafsson, Eric Rullman |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Aging medicine.medical_specialty Sarcopenia Nutritional Supplementation Geriatrik Skeletal muscle Walking Thigh Placebo Biochemistry Endocrinology Genetics medicine Vitamin D and neurology Humans Cross-sectional area Muscle Strength Vitamin D Muscle Skeletal Exercise Molecular Biology Computed tomography Hounsfield units Aged business.industry Cell Biology medicine.disease Preferred walking speed medicine.anatomical_structure Lower Extremity Geriatrics Dietary Supplements Physical therapy Female Ankle business |
| Popis: | Older adults are encouraged to engage in multicomponent physical activity, which includes aerobic and muscle-strengthening activities. The current work is an extension of the Vitality, Independence, and Vigor in the Elderly 2 (VIVE2) study - a 6-month multicenter, randomized, placebo-controlled trial of physical activity and nutritional supplementation in community dwelling 70-year-old seniors. Here, we examined whether the magnitude of changes in muscle size and quality differed between major lower-extremity muscle groups and related these changes to functional outcomes. We also examined whether daily vitamin-D-enriched protein supplementation could augment the response to structured physical activity. Forty-nine men and women (77 ± 5 yrs) performed brisk walking, muscle-strengthening exercises for the lower limbs, and balance training 3 times weekly for 6 months. Participants were randomized to daily intake of a nutritional supplement (20 g whey protein + 800 IU vitamin D), or a placebo. Muscle cross-sectional area (CSA) and radiological attenuation (RA) were assessed in 8 different muscle groups using single-slice CT scans of the hip, thigh, and calf at baseline and after the intervention. Walking speed and performance in the Short Physical Performance Battery (SPPB) were also measured. For both CSA and RA, there were muscle group × time interactions (P |
| Databáze: | OpenAIRE |
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