| Autor: |
Yong Wan, Zhihua Liu, Ivet Bahar, Kun-Liang Guan, Yi Huang, Mingjing He, Rui Zhu, Aiping Luo, Luca Ponzoni, Honghong Zhou, Zhuan Zhou |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22423101.v1 |
| Popis: |
Fig.S1 EIF3H promotes EMT and tumor invasion. Fig.S2 Clinico-pathological correlations of EIF3H. Fig.S3 Lys63-linked tetra-ubiquitin in-vitro cleavage assay. Fig.S4 GST Pull-down assay. Fig.S5 EIF3H binds to YAP1 and stabilizes YAP1. Fig.S6 EIF3H acts as a deubiquitinase that stabilizes YAP from ubiquitin-dependent degradation. Fig. S7 Molecular docking analysis. Fig. S8 EIF3H acts as a deubiquitinase that stabilizes YAP and promotes epithelial-mesenchymal transition. Fig. S9 Stabilization of YAP by EIF3H promotes breast cancer invasion and metastasis. Fig. S10 Blockade of EIF3H phosphorylation and YAP expression inhibit tumor cells invasion. Fig. S11 Stabilization of YAP by EIF3H promotes breast cancer invasion and metastasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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