Expression of the genes of interferons and other cytokines in normal and diseased tissues of man
| Autor: | M. G. Tovey |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Spleen
In Vitro Techniques Biology Virus Biological Factors Cellular and Molecular Neuroscience Liver disease Interferon Gene expression medicine Humans RNA Messenger Molecular Biology Pharmacology Regulation of gene expression Interleukin-6 Tumor Necrosis Factor-alpha Interleukins Interleukin Cell Biology medicine.disease medicine.anatomical_structure Gene Expression Regulation Immunology Cytokines Molecular Medicine Tumor necrosis factor alpha Interferons medicine.drug |
| Zdroj: | Experientia. 45:526-535 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01990502 |
| Popis: | Specific interferon genes are transcribed at low levels in the spleen, liver, and peripheral blood leukocytes of normal individuals in the apparent absence of virus infection while other interferon genes remain unexpressed in the same tissues. In contrast, the genes of cytokines such as IL-1, IL-6 and TNF are expressed at relatively high levels in the organs of normal individuals. The level of expression of the IL-1, IL-6 and TNF genes is markedly reduced in the livers of patients with autoimmune liver disease compared to the level of expression in the liver of normal individuals, whereas the expression of interferon genes is similar in both normal and diseased liver, suggesting that a defect in the expression of specific cytokines is associated with severe liver disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink