Evaluation of the ovarian reserve function in patients with metabolic syndrome in relation to healthy controls and different age groups
| Autor: | Oguz Kaan Unal, Fevzi Balkan, Celil Alper Usluogullari, Nurcan Cetin, Betul Usluogullari |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
medicine.medical_specialty Turkey Antral follicle Population Physiology Ovary Biology Follicle-stimulating hormone Young Adult Internal medicine Obstetrics and Gynaecology medicine Humans Obesity Ovarian reserve education Metabolic Syndrome education.field_of_study Estradiol Research Case-control study Obstetrics and Gynecology Anthropometry Luteinizing Hormone Middle Aged medicine.disease Radiography Endocrinology medicine.anatomical_structure Oncology Ovarian volume Case-Control Studies Female Metabolic syndrome Follicle Stimulating Hormone Gonadotropins |
| Zdroj: | Journal of Ovarian Research |
| ISSN: | 1757-2215 |
| DOI: | 10.1186/1757-2215-7-63 |
| Popis: | Objective: To evaluate the ovarian reserve function in female patients with metabolic syndrome (MetS). Methods: This study evaluated 136 subjects, 67 with MetS and 69 controls. Subjects were divided into three age groups. Group I included 49 subjects aged 20–29 years, 22 with MetS and 27 controls; group II included 45 subjects aged 30–39 years, 22 with MetS and 23 controls; and group III included 42 subjects aged 40–49 years, 23 with MetS and 19 controls. Demographic characteristics, anthropometrics, blood biochemistry, and gonadotrophic hormones were compared as total ovarian volume and antral follicle count on ovarian transvaginal ultrasonography. Results: Serum levels of FSH, LH, E2 and progesterone were similar in the MetS and control groups, while testosterone levels were significantly higher in MetS patients than controls, both in the overall population (p = 0.024) and in those aged 20–29 years (p = 0.018). Total ovarian volume was significantly lower in MetS patients than controls, in both the overall population (p = 0.003) and those aged 20–29 years (p = 0.018), while antral follicle counts were similar. Ovarian volume correlated positively with antral follicle count (AFC) (r = 0.37; p < 0.001) and negatively with age (r = 0.34; p < 0.001) and FSH concentration (r = 0.21; p = 0.013). AFC was negatively correlated with age (r = 0.36; p < 0.001). Conclusion: Ovarian reserve function is significantly lower in MetS patients than in healthy control subjects, particularly in women aged 20–29 years. |
| Databáze: | OpenAIRE |
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