Bio-therapeutic Potential and Cytotoxicity Assessment of Pectin-Mediated Synthesized Nanostructured Cerium Oxide

Autor: Satyendra Mishra, Sandeep N. Patil, Prapti Chaudhari, Jayasinh S. Paradeshi, Bhushan L. Chaudhari
Rok vydání: 2016
Předmět:
Cerium oxide
Citrus
food.ingredient
Photoluminescence
Materials science
Erythrocytes
Pectin
Nanoparticle
Bioengineering
02 engineering and technology
engineering.material
010402 general chemistry
Spectrum Analysis
Raman
01 natural sciences
Applied Microbiology and Biotechnology
Biochemistry
Hemolysis
Antioxidants
symbols.namesake
food
Picrates
X-Ray Diffraction
Spectroscopy
Fourier Transform Infrared
Organic chemistry
Humans
Fourier transform infrared spectroscopy
Particle Size
Molecular Biology
Cell Death
Biphenyl Compounds
Spectrometry
X-Ray Emission
General Medicine
Cerium
021001 nanoscience & nanotechnology
0104 chemical sciences
Anti-Bacterial Agents
Nanostructures
Biological Therapy
engineering
symbols
Pectins
Spectrophotometry
Ultraviolet
Biopolymer
Absorption (chemistry)
0210 nano-technology
Raman spectroscopy
Biotechnology
Nuclear chemistry
Zdroj: Applied biochemistry and biotechnology. 180(4)
ISSN: 1559-0291
Popis: In the present studies, renewable and nontoxic biopolymer, pectin, was extracted from Indian red pomelo fruit peels and used for the synthesis of cerium oxide nanoparticles (CeO2-NPs) having bio-therapeutic potential. The structural information of extracted pectin was investigated by FTIR and NMR spectroscopic techniques. Physicochemical characteristics of this pectin suggested its application in the synthesis of metal oxide nanoparticles. Using this pectin as a template, CeO2-NPs were synthesized by simple, one step and eco-friendly approach. The UV–Vis spectrum of synthesized CeO2-NPs exhibited a characteristic absorption peak at wavelength 345 nm, which can be assigned to its intrinsic band gap (3.59 eV) absorption. Photoluminescence measurements of CeO2-NPs revealed that the broad emission was composed of seven different bands. FTIR analysis ensured involvement of pectin in the formation and stabilization of CeO2-NPs. FT-Raman spectra showed a sharp Raman active mode peak at 461.8 cm−1 due to a symmetrical stretching mode of Ce–O vibration. DLS, FESEM, EDX, and XRD analysis showed that the CeO2-NPs prepared were polydispersed, spherical shaped with a cubic fluorite structure and average particle size ≤40 nm. These CeO2-NPs displayed broad spectrum antimicrobial activity, antioxidant potential, and non-cytotoxic nature.
Databáze: OpenAIRE
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