Response to chemotherapy in gastric adenocarcinoma with diffusion-weighted MRI and18F-FDG-PET/CT: Correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade

Autor: Alessandro Del Maschio, Antonio Esposito, Luca Albarello, Francesca Gallivanone, Luigi Gianolli, Carlo Staudacher, Francesco De Cobelli, Elena Orsenigo, Francesco Giganti, Elena Mazza, Carla Canevari, Alessandro Ambrosi, Isabella Castiglioni
Přispěvatelé: Giganti, F, De Cobelli, F, Canevari, C, Orsenigo, E, Gallivanone, F, Esposito, A, Castiglioni, I, Ambrosi, A, Albarello, L, Mazza, E, Gianolli, L, Staudacher, C, Del Maschio, A, DE COBELLI, Francesco, Esposito, Antonio, Ambrosi, Alessandro, DEL MASCHIO, Alessandro
Rok vydání: 2013
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Statistics as Topic
Partial volume
Standardized uptake value
Adenocarcinoma
Multimodal Imaging
DW-MRI
Fluorodeoxyglucose F18
Gastrectomy
Stomach Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Image Interpretation
Computer-Assisted
medicine
Humans
Effective diffusion coefficient
Radiology
Nuclear Medicine and imaging
Prospective Studies
Neoadjuvant therapy
Aged
Neoplasm Staging
Tumor Regression Grade
Chemotherapy
medicine.diagnostic_test
business.industry
gastric cancer
Stomach
Middle Aged
Image Enhancement
Combined Modality Therapy
Neoadjuvant Therapy
body regions
Diffusion Magnetic Resonance Imaging
Treatment Outcome
PET/MRI
PET
Positron emission tomography
Positron-Emission Tomography
TRC
Female
Radiology
Tomography
X-Ray Computed
business
Nuclear medicine
ADG
Diffusion MRI
Zdroj: Journal of magnetic resonance imaging (Online) 40 (2014): 1147–1157. doi:10.1002/jmri.24464
info:cnr-pdr/source/autori:Francesco Giganti 1; Francesco De Cobelli 1; Carla Canevari 2,3; Elena Orsenigo 4; Francesca Gallivanone 3; Antonio Esposito 1; Isabella Castiglioni 3; Alessandro Ambrosi 5; Luca Albarello 6; Elena Mazza 7; Luigi Gianolli 2; Carlo Staudacher 4; Alessandro Del Maschio 1./titolo:Response to chemotherapy in gastric adenocarcinoma with diffusion-weighted MRI and 18 F-FDG-PET%2FCT: Correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade/doi:10.1002%2Fjmri.24464/rivista:Journal of magnetic resonance imaging (Online)/anno:2014/pagina_da:1147/pagina_a:1157/intervallo_pagine:1147–1157/volume:40
ISSN: 1053-1807
DOI: 10.1002/jmri.24464
Popis: PURPOSE:To assess whether changes in diffusion-weighted MRI (DW-MRI) and (18) F-fluoro-2-deoxyglucose positron emission tomography/computed tomography ((18) F-FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA).MATERIALS AND METHODS:Seventeen patients underwent both DW-MRI and (18) F-FDG-PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC-SUVBW-mean ) were evaluated and compared with histopathological TRG.RESULTS:Pre- and post-NT and percentage changes for ADC and PVC-SUVBW-mean were assessed. Post-NT ADC and ΔADC showed a significant inverse correlation with TRG (r = -0.71; P = 0.0011 and r = -0.78; P = 0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1-2-3) and nonresponders (TRG 4-5) (P = 0.0009; P = 0.000082, respectively). No correlations with TRG were found for pre-NT ADC and for all PVC-SUVBW-mean values as well as between ΔADC and Δ PVC-SUVBW-mean .CONCLUSION:DW-MRI seems more accurate than (18) F-FDG-PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GA. PurposeTo assess whether changes in diffusion-weighted MRI (DW-MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA).Materials and MethodsSeventeen patients underwent both DW-MRI and 18F-FDG-PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC-SUVBW-mean) were evaluated and compared with histopathological TRG.ResultsPre- and post-NT and percentage changes for ADC and PVC-SUVBW-mean were assessed. Post-NT ADC and ΔADC showed a significant inverse correlation with TRG (r = −0.71; P = 0.0011 and r = −0.78; P = 0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1–2-3) and nonresponders (TRG 4–5) (P = 0.0009; P = 0.000082, respectively). No correlations with TRG were found for pre-NT ADC and for all PVC-SUVBW-mean values as well as between ΔADC and Δ PVC-SUVBW-mean.ConclusionDW-MRI seems more accurate than 18F-FDG-PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GA
Databáze: OpenAIRE
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