Extended-spectrum beta-lactamase production and multi-drug resistance among Enterobacteriaceae isolated in Addis Ababa, Ethiopia

Autor:	Hiwot Ketema Woldemariam, Kassu Desta Tullu, Tesfaye Legesse Bedada, Abebe Aseffa Negeri, Dejenie Shiferaw Teklu, Melese Hailu Legese
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Microbiology (medical) Veterinary medicine Cefotaxime medicine.medical_treatment Cefepime 030106 microbiology Ceftazidime Drug resistance Clinical specimens lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Enterobacteriaceae Clavulanic acid MDR medicine polycyclic compounds Pharmacology (medical) lcsh:RC109-216 030212 general & internal medicine biology business.industry Public Health Environmental and Occupational Health Amoxicillin biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses Infectious Diseases ESBLs Beta-lactamase Addis Ababa Ethiopia business medicine.drug
Zdroj:	Antimicrobial Resistance and Infection Control, Vol 8, Iss 1, Pp 1-12 (2019)
ISSN:	2047-2994
DOI:	10.1186/s13756-019-0488-4
Popis:	Background The global emergence and spread of extended-spectrum beta-lactamases (ESBLs) producing Enterobacteriaceae have been threatening the ability to treat an infection. Hence, this study aimed to determine the prevalence of ESBL-producing and multi-drug resistance (MDR) Enterobacteriaceae (ESBLs-E) from different clinical specimens in Addis Ababa, Ethiopia. Methods A cross-sectional study was conducted from January 1 to May 30, 2017. A total of 426 Enterobacteriaceae isolates were identified from clinical specimens. The isolates were collected from four laboratories. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method on Muller Hinton agar (MHA). All Enterobacteriaceae were screened for ESBLs production using cefotaxime and ceftazidime as per CLSI guideline. Each ESBL screening positive Enterobacteriaceae were confirmed by a combination disk test (CDT). Data were entered and analyzed by using SPSS version-20. Result The most frequent Enterobacteriaceae were E. coli 228 (53.5%) and K. pneumoniae 103 (24.1%). The magnitude of ESBLs-E was 57.7% (246/426). The highest frequencies of ESBLs-E were observed in blood specimesns (84.4%) and the highest ESBLs production was observed in K. pneumoniae (85.4%). The highest resistance level was seen to sulfamethoxazole-trimethoprim (77.0%), amoxicillin with clavulanic acid (71.6%), cefotaxime (62.2%), cefepime (60.3%) and ceftazidime (60.8%). The overall magnitude of multi-drug resistance (MDR) level was 68.3%. Of ESBLs-E, 96.3% of them were MDR (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1499e164b29e8a892ae2aaa1add48c7e http://link.springer.com/article/10.1186/s13756-019-0488-4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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