Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: A matched case-control study
| Autor: | Yee Sin Leo, Tsin W. Yeo, Junxiong Pang, Jung Pu Hsu, David C. Lye |
|---|---|
| Přispěvatelé: | Lee Kong Chian School of Medicine (LKCMedicine) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Abdominal pain Adolescent Epidemiology 030231 tropical medicine Disease macromolecular substances Hematocrit Article Dengue fever Dengue 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Diabetes Mellitus Humans 030212 general & internal medicine Intensive care medicine Child Asthma Aged Multidisciplinary medicine.diagnostic_test business.industry musculoskeletal neural and ocular physiology Case-control study Middle Aged medicine.disease nervous system Risk factors Cardiovascular Diseases Case-Control Studies Female medicine.symptom business |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep39872 |
| Popis: | Progression to severe organ involvement due to dengue infection has been associated with severe dengue disease, intensive care treatment, and mortality. However, there is a lack of understanding of the impact of pre-existing comorbidities and other risk factors of severe organ involvement among dengue adults. The aim of this retrospective case-control study is to characterize and identify risk factors that predispose dengue adults at risk of progression with severe organ involvement. This study involved 174 dengue patients who had progressed with severe organ involvement and 865 dengue patients without severe organ involvement, matched by the year of presentation of the cases, who were admitted to Tan Tock Seng Hospital between year 2005 and 2008. Age group of 60 years or older, diabetes, cardiac disorders, asthma, and having two or more pre-existing comorbidities were independent risk factors of severe organ involvement. Abdominal pain, clinical fluid accumulation, and hematocrit rise and rapid platelet count drop at presentation were significantly associated with severe organ involvement. These risk factors, when validated in a larger study, will be useful for triage by clinicians for prompt monitoring and clinical management at first presentation, to minimize the risk of severe organ involvement and hence, disease severity. NRF (Natl Research Foundation, S’pore) NMRC (Natl Medical Research Council, S’pore) Published version |
| Databáze: | OpenAIRE |
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