Neural Activation During Mental Rotation in Complete Androgen Insensitivity Syndrome: The Influence of Sex Hormones and Sex Chromosomes
| Autor: | Peggy T. Cohen-Kettenis, Julie Bakker, Dick J. Veltman, Arianne B. Dessens, Judy van Hemmen, Elseline Hoekzema |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Child and Adolescent Psychiatry / Psychology, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Anatomy and neurosciences, Medical psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Rotation medicine.drug_class Cognitive Neuroscience Feminization (biology) Neuropsychological Tests 050105 experimental psychology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Complete androgen insensitivity syndrome Internal medicine medicine Humans 0501 psychology and cognitive sciences Gonadal Steroid Hormones Testosterone Testicular feminization Brain Mapping Sex Characteristics Sexual differentiation Sex Chromosomes 05 social sciences Brain Androgen-Insensitivity Syndrome medicine.disease Androgen Magnetic Resonance Imaging Endocrinology Space Perception Imagination Androgen insensitivity syndrome Female Psychology 030217 neurology & neurosurgery Sex characteristics |
| Zdroj: | van Hemmen, J, Veltman, D J, Hoekzema, E, Cohen-Kettenis, P T, Dessens, A B & Bakker, J 2016, ' Neural Activation During Mental Rotation in Complete Androgen Insensitivity Syndrome: The Influence of Sex Hormones and Sex Chromosomes ', Cerebral Cortex, vol. 26, no. 3, pp. 1036-1045 . https://doi.org/10.1093/cercor/bhu280 Cerebral Cortex, 26(3), 1036-45. Oxford University Press Cerebral Cortex, 26(3), 1036-1045. Oxford University Press |
| ISSN: | 1047-3211 |
| DOI: | 10.1093/cercor/bhu280 |
| Popis: | Sex hormones, androgens in particular, are hypothesized to play a key role in the sexual differentiation of the human brain. However, possible direct effects of the sex chromosomes, that is, XX or XY, have not been well studied in humans. Individuals with complete androgen insensitivity syndrome (CAIS), who have a 46,XY karyotype but a female phenotype due to a complete androgen resistance, enable us to study the separate effects of gonadal hormones versus sex chromosomes on neural sex differences. Therefore, in the present study, we compared 46,XY men (n = 30) and 46,XX women (n = 29) to 46,XY individuals with CAIS (n = 21) on a mental rotation task using functional magnetic resonance imaging. Previously reported sex differences in neural activation during mental rotation were replicated in the control groups, with control men showing more activation in the inferior parietal lobe than control women. Individuals with CAIS showed a female-like neural activation pattern in the parietal lobe, indicating feminization of the brain in CAIS. Furthermore, this first neuroimaging study in individuals with CAIS provides evidence that sex differences in regional brain function during mental rotation are most likely not directly driven by genetic sex, but rather reflect gonadal hormone exposure. |
| Databáze: | OpenAIRE |
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