Mitochondrial toxicity of nanomaterials
| Autor: | Ying Ma, Yuna Cao, Ting Zhang, Daming Wu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Environmental Engineering
010504 meteorology & atmospheric sciences 010501 environmental sciences Mitochondrion 01 natural sciences Mitochondrial Membrane Transport Proteins chemistry.chemical_compound Organelle medicine Environmental Chemistry Humans Respiratory function Waste Management and Disposal 0105 earth and related environmental sciences biology Chemistry Mitochondrial Permeability Transition Pore MPTP Cytochrome c Environmental Exposure medicine.disease Pollution Cell biology Mitochondria Nanostructures Mitochondrial toxicity Mitochondrial permeability transition pore Toxicity biology.protein |
| Zdroj: | The Science of the total environment. 702 |
| ISSN: | 1879-1026 |
| Popis: | In recent years, nanomaterials have been widely applied in electronics, food, biomedicine and other fields, resulting in increased human exposure and consequent research focus on their biological and toxic effects. Mitochondria, the main target organelle for nanomaterials (NM), play a critical role in their toxic activities. Several studies to date have shown that nanomaterials cause alterations in mitochondrial morphology, mitochondrial membrane potential, opening of the mitochondrial permeability transition pore (MPTP) and mitochondrial respiratory function, and promote cytochrome C release. An earlier mitochondrial toxicity study of NMs additionally reported induction of mitochondrial dynamic changes. Here, we have reviewed the mitochondrial toxicity of NMs and provided a scientific basis for the contribution of mitochondria to the toxicological effects of different NMs along with approaches to reduce mitochondrial and, consequently, overall toxicity of NMs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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