Prevalence and factors associated with osteoporosis and fragility fractures in patients with primary Sjogren syndrome
| Autor: | Natalia Cid, Begoña Moreira, Blanca García Magallón, Hèctor Corominas, Cristina Bohórquez, José M. Pego-Reigosa, Jesús Alberto García Vadillo, José Luis Andreu, Carlos Sánchez-Piedra, Ruth López-González, Vicenç Torrente-Segarra, Angel Garcia Aparicio, Esther Ruiz Lucea, Mónica Fernández Castro, Beatriz Rodríguez, J. Belzunegui, Carlos Guillen Astete, Víctor Martínez Taboada, Sheila Melchor, Carlos Galisteo, C. Erausquin, Ivan Castellví, José Rosas, Tarek Carlos Salman-Monte, Clara Moriano, Raúl Menor, Jorge Juan Gonzalez Martin, Francisco Javier López Longo, Susana Gil Barato, Enrique Raya, Enrique Júdez, Francisco Javier Narváez, Sara Manrique-Arija, Oscar Illera, Alejandro Olivé, Javier Loricera |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Immunology Osteoporosis Osteoporotic fractures Disease Bone remodeling 03 medical and health sciences 0302 clinical medicine Fragility Rheumatology Internal medicine Epidemiology medicine Humans Immunology and Allergy In patient Registries 030212 general & internal medicine Sjogren syndrome Glucocorticoids Aged Aged 80 and over 030203 arthritis & rheumatology business.industry Age Factors Middle Aged medicine.disease Cross-Sectional Studies Sjogren's Syndrome Spain Case-Control Studies Disease Progression Female Menopause business Osteoporotic Fractures |
| Zdroj: | Rheumatology International r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname RHEUMATOLOGY INTERNATIONAL r-FISABIO. Repositorio Institucional de Producción Científica r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| ISSN: | 0172-8172 |
| Popis: | This study aimed at determining socio-demographic and clinical factors of primary Sjögren syndrome (pSS) associated with osteoporosis (OP) and fragility fracture. SJOGRENSER is a cross-sectional study of patients with pSS, classified according to American European consensus criteria developed in 33 Spanish rheumatology departments. Epidemiological, clinical, serological and treatment data were collected and a descriptive analysis was conducted. Bivariate and multivariate analyses were performed using a binomial logistic regression to study the factors associated with OP and fragility fracture in pSS. 437 patients were included (95% women, with a median age of 58.6 years). 300 women were menopausal (76.4%). Prevalence of OP was 18.5% [in men (N = 21) this measured 19%]. A total of 37 fragility fractures were recorded. In the multivariate analysis, there was an association between OP and age: in the 51-64 age range (menopausal women), the OR measured 9.993 (95% CI 2301-43,399, p = 0.002); In the age 64 years group, OR was 20.610 (4.679-90.774, p 0.001); between OP and disease duration, OR was 1.046 (1.008-1085, p = 0.017); past treatment with corticosteroids, OR 2.548 (1.271-5.105, p = 0.008). Similarly, an association was found between fragility fractures and age: in the 51-64 age group, OR measured 5.068 (1.117-22,995, p = 0.035), age 64 years, OR was 7.674 (1.675-35,151, p 0.009); disease duration, OR 1.049 (CI 1.003-1097, p 0.036) and the ESSDAI index, OR 1.080 (1.029-1134, p = 0.002). Patients with pSS can develop osteoporosis and fragility fractures over the course of the disease. Age, corticosteroids treatment and disease duration were associated with the development of OP. Disease duration and ESSDAI were associated with the development of fractures in patients with pSS. |
| Databáze: | OpenAIRE |
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