Cellular immunotherapy with ex vivo expanded cord blood T cells in a humanized mouse model of EBV-associated lymphoproliferative disease
| Autor: | Nakaba Ochiai, Fuyuko Kawano, Tomohiro Morio, Shigeyoshi Fujiwara, Ken-Ichi Imadome, Masashi Mochizuki, Go Matsuda, Norio Shimizu |
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| Rok vydání: | 2015 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human T-Lymphocytes Immunology Mice SCID medicine.disease_cause Immunotherapy Adoptive Donor lymphocyte infusion Virus Mice Immune system hemic and lymphatic diseases Immunology and Allergy Medicine Animals Humans Cell Proliferation Mice Knockout business.industry Fetal Blood Epstein–Barr virus Lymphoproliferative Disorders Disease Models Animal Oncology Cord blood Humanized mouse Female Lymphoproliferative disease business Ex vivo Interleukin Receptor Common gamma Subunit |
| Zdroj: | Immunotherapy. 7(4) |
| ISSN: | 1750-7448 |
| Popis: | Background: Donor lymphocyte infusion is not feasible in recipients of cord blood transplantation. Aim: We investigated whether infusion of T cells expanded from cord blood is effective in the treatment of model mice of Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD). Materials & methods: Humanized mice with reconstituted human immune system were prepared and LPD was induced by inoculating EBV intravenously. T cells were expanded from the same sample of cord blood as used for generation of humanized mice and infused to EBV-infected humanized mice. Results: Mice treated with expanded cord blood T cells lived significantly longer than control mice (p = 0.036). Conclusion: Infusion of T cells expanded from cord blood was effective in the treatment of model mice for EBV-associated LPD. |
| Databáze: | OpenAIRE |
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