Efficiency comparison of nylon-6-based solid-phase and stir bar sorptive extractors for carbamazepine extraction
| Autor: | Ali Nokhodchi, Sima Alvani-Alamdari, Abolghasem Jouyban, Maryam Khoubnasabjafari, Elaheh Rahimpour |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Materials science Bar (music) Polymers Clinical Biochemistry 030226 pharmacology & pharmacy 01 natural sciences Analytical Chemistry Molecular Imprinting 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Phase (matter) Caprolactam Humans General Pharmacology Toxicology and Pharmaceutics Chromatography High Pressure Liquid Aged Chromatography 010401 analytical chemistry Extraction (chemistry) Solid Phase Extraction General Medicine Middle Aged Silicon Dioxide Ferrosoferric Oxide 0104 chemical sciences Medical Laboratory Technology Nylon 6 Carbamazepine chemistry Efficiency comparison Female |
| Zdroj: | Bioanalysis. 11(9) |
| ISSN: | 1757-6199 |
| Popis: | Aim: Two approaches based on molecularly imprinted polymers-stir bar sorptive extraction (MIP-SBSE) and -magnetic solid-phase extraction (MIP-MSPE) have been used for extraction of carbamazepine (CBZ) from serum samples. Methodology: In MSPE and SBSE, development was achieved by employing a polycaprolactam coating. The Cecil® chromatographic system equipped with a UV-Vis detector was used for analytical determination of CBZ. Results: The linearity of calibration curves was in the concentration ranges of 0.2–12 and 0.05–12 μg ml-1 for MIP-SBSE and MIP-MSPE, respectively. Conclusion: MIP-MSPE was selected in preference to MIP-SBSE since lower limits of detection were achievable using MIP-MSPE method. The CBZ-MIP-MSPE-HPLC-UV method was successfully applied to CBZ determination in real serum samples of patients receiving CBZ. |
| Databáze: | OpenAIRE |
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