| Autor: |
Kellie S, Gross, Carnita M, Lincoln, McKenna M, Anderson, Grace E, Geiger, Karyn M, Frick |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Psychoneuroendocrinology |
| ISSN: |
0306-4530 |
| DOI: |
10.1016/j.psyneuen.2022.105773 |
| Popis: |
Hippocampal plasticity and memory are modulated by the potent estrogen 17β-estradiol (E(2)). Research on the molecular mechanisms of hippocampal E(2) signaling has uncovered multiple intracellular pathways that contribute to these effects, but few have questioned the role that extracellular signaling processes may play in E(2) action. Modification of the extracellular matrix (ECM) by proteases like matrix metalloproteinase-9 (MMP-9) is critical for activity-dependent remodeling of synapses, and MMP-9 activity is required for hippocampal learning and memory. Yet little is known about the extent to which E(2) regulates MMP-9 in the hippocampus, and the influence this interaction may have on hippocampal memory. Here, we examined the effects of hippocampal MMP-9 activity on E(2)-induced enhancement of spatial and object recognition memory consolidation. Post-training bilateral infusion of an MMP-9 inhibitor into the dorsal hippocampus of ovariectomized female mice blocked the enhancing effects of E(2) on object placement and object recognition memory, supporting a role for MMP-9 in estrogenic regulation of memory consolidation. E(2) also rapidly increased the activity of dorsal hippocampal MMP-9 without influencing its protein expression, providing further insight into hippocampal E(2)/MMP-9 interactions. Together, these results provide the first evidence that E(2) regulates MMP-9 to modulate hippocampal memory and highlight the need to further study estrogenic regulation of extracellular modification. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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