Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry
| Autor: | Jae Sung Pyo, Janghyun Park, Deukjoon Kim, Sung Won Kwon, Tae Hyung Yoon, Hye Kyoung Jeong, Sangaeh Park, Dong Mi Choi |
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| Rok vydání: | 2008 |
| Předmět: |
Magnetic Resonance Spectroscopy
Sildenafil Phosphodiesterase Inhibitors Food Contamination Ring (chemistry) Mass spectrometry Mass Spectrometry Piperazines Sildenafil Citrate Analytical Chemistry law.invention chemistry.chemical_compound Column chromatography Vardenafil Dihydrochloride Photodiode array detector law medicine Environmental Chemistry Sulfones Pharmacology Chromatography Molecular Structure Triazines Imidazoles Nuclear magnetic resonance spectrometry Reference Standards Photodiode chemistry Vardenafil Purines Agronomy and Crop Science Food Science medicine.drug Chromatography Liquid |
| Zdroj: | Journal of AOAC International. 91(3) |
| ISSN: | 1060-3271 |
| Popis: | Two analogs of sildenafil and vardenafil in food were detected by column liquid chromatography (LC) with a photodiode array detector. They were isolated by preparative LC; their structures were established by mass spectrometry and nuclear magnetic resonance spectrometry. One analog was found to be methisosildenafil (compound A), 5-(5-(3,5-dimethylpiperazin-1-ylsulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]-pyrimidin-7(6H)-one. It is a sildenafil analog with a dimethylpiperazine ring substituted for the methylpiperazine group. The second analog, hydroxyvardenafil (compound B) is reported for the first time in this study. Hydroxyvardenafil's International Union of Pure and Applied Chemistry name is 2-(2-ethoxy-5-(4-(2-hydroxyethyl)-piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[ 1,5-f][1,2,4]triazin-4(3H)-one. The novel vardenafil analog has a hydroxyl group added to the ethylpiperazine group. |
| Databáze: | OpenAIRE |
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