In vivo imaging of Lyme arthritis in mice by [18F]fluorodeoxyglucose positron emission tomography/computed tomography
| Autor: | Annukka Pietikäinen, Jukka Hytönen, Riikka Siitonen, Heidi Liljenbäck, Mirva Söderström, Anne Roivainen, Olli Eskola |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Immunology Arthritis Computed tomography ta3111 Lyme Arthritis Fluorodeoxyglucose positron emission tomography 03 medical and health sciences Rheumatology Immunology and Allergy Medicine Borrelia burgdorferi biology medicine.diagnostic_test business.industry ta1182 General Medicine bacterial infections and mycoses biology.organism_classification medicine.disease Tibiotarsal joint 030104 developmental biology Positron emission tomography business Nuclear medicine Preclinical imaging |
| Zdroj: | Scandinavian Journal of Rheumatology. 47:37-47 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.1080/03009742.2017.1287306 |
| Popis: | Objective: Lyme borreliosis (LB) is a tick-borne infectious disease caused by Borrelia burgdorferi spirochaetes, which are able to disseminate from the tick-bite site to distant organs. Mouse models are widely used to study LB and especially Lyme arthritis (LA), but only a few whole-animal in vivo imaging studies on the pathogenesis of B. burgdorferi infection in mice have been published so far. The existing imaging techniques have their drawbacks and, therefore, novel tools to complement the array of available LB imaging methodologies are needed.Method: The applicability of positron emission tomography combined with computed tomography (PET/CT) imaging was evaluated as a method to monitor LB and especially LA in the C3H/HeN mouse model infected with wild-type B. burgdorferi N40 bacteria. The imaging results were compared with the traditional LA analysis methods, such as tibiotarsal joint swelling and histopathological assessment of joint inflammation.Results: PET/CT imaging provided high-resolution image... |
| Databáze: | OpenAIRE |
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