Effect of low-dose omeprazole on gastric acid secretion in duodenal ulcer patients
| Autor: | G. Mclauchlan, G. P. Crean, K. E. L. Mccoll |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastroenterology Gastric Acid Basal (phylogenetics) Double-Blind Method Internal medicine Humans Medicine Pharmacology (medical) Secretion Dosing Omeprazole Hepatology business.industry Low dose Middle Aged Duodenal ulcer Duodenal Ulcer Gastric acid Female business Gastric acid output medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 2:263-268 |
| ISSN: | 1365-2036 0269-2813 |
| DOI: | 10.1111/j.1365-2036.1988.tb00696.x |
| Popis: | The effect of 7 days of oral dosing with 5 mg day-1 and 20 mg day-1 omeprazole on basal and pentagastrin-stimulated gastric acid output was studied in nine duodenal ulcer patients. Basal acid output measured 5-6 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and by 90% on 20 mg omeprazole (P less than 0.05 and P less than 0.01, respectively). Peak acid output measured 6-7 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and 97% on 20 mg omeprazole (P less than 0.01 for each). There was a wide interindividual variation in response to the 5 mg dose, with five of the nine patients having more than 90% inhibition of peak acid output, but two patients having less than 40% inhibition. This unpredictable response to daily low-dose omeprazole therapy makes it unsuitable for maintenance treatment. |
| Databáze: | OpenAIRE |
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