The great cholesterol myth; unfortunate consequences of Brown and Goldstein's mistake
| Autor: | D. D. Adams |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Arterial disease Arteriosclerosis Familial hypercholesterolemia Pathogenesis Cholesterol Dietary Hyperlipoproteinemia Type II chemistry.chemical_compound Internal medicine Vitamin D and neurology Medicine Animals Humans Ldl cholesterol Evidence-Based Medicine business.industry Cholesterol General Medicine Arteries Mythology medicine.disease Disease Models Animal Fat-Soluble Vitamin Endocrinology chemistry business |
| Zdroj: | QJM : monthly journal of the Association of Physicians. 104(10) |
| ISSN: | 1460-2393 |
| Popis: | Following their Nobel Prize-winning discovery of the defective gene causing familial hypercholesterolaemia, Brown and Goldstein misunderstood the mechanism involved in the pathogenesis of the associated arterial disease. They ascribed this to an effect of the high levels of cholesterol circulating in the blood. In reality, the accelerated arterial damage is likely to be a consequence of more brittle arterial cell walls, as biochemists know cholesterol to be a component of them which modulates their fluidity, conferring flexibility and hence resistance to damage from the ordinary hydrodynamic blood forces. In the absence of efficient receptors for LDL cholesterol, cells will be unable to use this component adequately for the manufacture of normally resilient arterial cell walls, resulting in accelerated arteriosclerosis. Eating cholesterol is harmless, shown by its failure to produce vascular accidents in laboratory animals, but its avoidance causes human malnutrition from lack of fat-soluble vitamins, especially vitamin D. |
| Databáze: | OpenAIRE |
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