Intra- and multicenter reproducibility of pulsed, continuous and pseudo-continuous arterial spin labeling methods for measuring cerebral perfusion
| Autor: | Jeroen Hendrikse, S. Gevers, Aart J. Nederveen, Reinoud P H Bokkers, Matthias J.P. van Osch, Dennis A. Kies, Charles B. L. M. Majoie, Wouter M. Teeuwisse |
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| Přispěvatelé: | University of Groningen, Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, ANS - Amsterdam Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male regional variability Perfusion Imaging Perfusion scanning multicenter Magnetic resonance angiography GRADIENT medicine otorhinolaryngologic diseases Humans INVERSION Cerebral perfusion pressure BRAIN reproducibility Reproducibility Brain Mapping medicine.diagnostic_test BLOOD-FLOW business.industry Reproducibility of Results Blood flow Repeatability Arteries Middle Aged reference values arterial spin labeling SIGNAL TIME MODEL Neurology Regional Blood Flow Reference values Cerebrovascular Circulation FMRI Arterial spin labeling Female Spin Labels Original Article Neurology (clinical) Cardiology and Cardiovascular Medicine Nuclear medicine business Magnetic Resonance Angiography MRI |
| Zdroj: | Journal of Cerebral Blood Flow and Metabolism, 31(8), 1706-1715. SAGE Publications Inc. Journal of cerebral blood flow and metabolism, 31(8), 1706-1715. Nature Publishing Group |
| ISSN: | 0271-678X |
| Popis: | Intra- and multicenter reproducibility of currently used arterial spin labeling (ASL) methods were assessed at three imaging centers in the Netherlands, equipped with Philips 3TMR scanners. Six healthy participants were scanned twice at each site. The imaging protocol consisted of continuous ASL (CASL), pseudo-continuous ASL (p-CASL) with and without background suppression, pulsed ASL (PASL) with single and multiple inversion times (TIs), and selective ASL for segmentation. Reproducibility was expressed in terms of the coefficient of repeatability and the repeatability index. Voxelwise analysis of variance was performed, yielding brain maps that reflected regional variability. Intra- and multicenter reproducibility were comparable for all methods, except for single TI PASL, with better intracenter reproducibility (F-test of equality of two variances, P < 0.05). Pseudo-continuous ASL and multi TI PASL varied least between sites. Variability maps of all methods showed most variability near brain-feeding arteries within sessions and in gray matter between sessions. On the basis of the results of this study, one could consider the use of reference values in clinical routine, with whole-brain p-CASL perfusion varying < 20% over repeated measurements within the same individuals considered to be normal. Knowledge on regional variability allows for the use of perfusion-weighted images in the assessment of local cerebral pathology. |
| Databáze: | OpenAIRE |
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